abm编号系统使用知识数据库和从头开始方法的组合,从基本序列建模抗体的三级结构(参见samudrala等,1999,在proteins,structure,function and genetics suppl.,3:194-198中的“ab initio protein structure prediction using a combinedhierarchicalapproach”描述的那些)。接触定义基于可用复杂晶体结构的分析(参见例如maccallum等,...
[2]. Li Y, et al. Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab. Cell Rep. 2018 Oct 23;25(4):909-920.e4. [3]. Bitra A, et al. Crystal structure of the m4-1BB/4-1BBL complex reveals an unusual dimeric ligand that undergoes ...
(ECD) of 4-1BBL has a jelly-roll, beta -sandwich tertiary structure that is similar to other TNFSF members. There is only one cysteine in the human ECD, and no potential N-linked glycosylation sites. The potential exists, however, for O-linked glycosylation. The human 4-1BBL ECD ...
However, a published crystal structure of human 4-1BBL suggests that it may be unique in this regard, exhibiting a three-bladed propeller-like trimer assembly that is distinctly different from that observed in other family members. This unusual structure also suggests that the human 4-1BB/4-1...
BD Horizon RB780 Mouse Anti-Human CD137 (4-1BB) information, including chemical properties, structure, melting point, boiling point, density, formula, molecular weight, uses, prices, suppliers, SDS and more, available at Chemicalbook.
(ECD) of 4-1BBL has a jelly-roll, beta -sandwich tertiary structure that is similar to other TNFSF members. There is only one cysteine in the human ECD, and no potential N-linked glycosylation sites. The potential exists, however, for O-linked glycosylation. The human 4-1BBL ECD ...
The ectodomain forms a homotrimer with an extended, three-bladed propeller structure that differs from trimers formed by other members of the tumor necrosis factor (TNF) superfamily. Based on the 4-1BBL structure, we modeled its complex with 4-1BB, which was consistent with images obtained ...
4-1BB (HUMAN):FC (HUMAN) structure CAS No. Chemical Name: 4-1BB (HUMAN):FC (HUMAN) Synonyms HUMAN 4-1BB/FC CHIMERA;CD137L, SOLUBLE (HUMAN);4-1BB (HUMAN):FC (HUMAN);CD137 (HUMAN):FC (HUMAN);ANTI-4-1BBL SOLUBLE (HUMAN);TNFRSF 9 (HUMAN):FC (HUMAN);ANTI-TNFSF 9 ...
Furthermore, our ligand-only structure differs from previously published data. Utomilumab, a ligand-blocking antibody, binds 4-1BB between CRDs 3 and 4. In contrast, urelumab binds 4-1BB CRD-1, away from the ligand binding site. Finally, cell-based assays demonstrate utomilumab is a ...
et al. Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab. Nat. Commun. 9, 4679 (2018). Article ADS PubMed PubMed Central Google Scholar Segal, N. H. et al. I Study of single-agent utomilumab (PF-05082566), a 4-1...