4-1BB expression is induced upon PHA stimulation in both the naive (CD45RAhi-CD45ROlo/) and the memory (CD45RAlo/- ROhi) T cell populations. Virtually all CD45RAhiROlo/cells upon culture in PHA give rise to an intermediate CD45RAhiROhi4-1BB+transitional cell and subsequently CD45RA...
3.Pollok， K.E.， et al.， Inducible T cell antigen 4-1BB. Analysis of expression and function. Journal of Immunology （Baltimore， Md.: 1950）， 1993. 150（3）: p. 771-781.4.Horton， B.L.， et al.， Intratumoral CD8+ T-cell Apoptosis Is a Major Component of T-cell Dysfunction...
3. Pollok, K.E., et al.,Inducible T cell antigen 4-1BB. Analysis of expression and function.Journal of Immunology (Baltimore, Md.: 1950), 1993.150(3): p. 771-781. 4. Horton, B.L., et al.,Intratumoral CD8+ T-cell Apoptosis Is a Major Component of T-cell Dysfunction and Impedes...
4-1BB expression is induced upon PHA stimulation in both the naive (CD45RAhi-CD45ROlo/-) and the memory (CD45RAlo/-ROhi) T cell populations. Virtually all CD45RAhiROlo/- cells upon culture in PHA give rise to an intermediate CD45RAhiROhi 4-1BB+ transitional cell and subsequently ...
GITR-dependent regulation of 4-1BB expression: implications for T cell memory and anti-4-1BB-induced pathology. GITR- Dependent Regulation of 4-1BB Expression: Implications for T Cell Memory and Anti-4- 1BB-Induced Pathology. J Immunol 190: 4627-4639... GHY Lin,LM Snell,ME Wortzman,....
Here, we investigated the transcriptional machinery required for T cell receptor (TCR) activation-dependent induction of 4-1BB expression in CD3-CEM cells treated with phorbol myristate acetate and ionomycin. Using 5′-deletion constructs of 4-1BB promoter in luciferase reporter assays, we ...
Expression of 4-1BB and 4-1BBL mRNA and protein in mouse thymocytes during thymus regeneration. B6 mice (8-10-week-old) were given a single intraperitoneal dose of cyclophosphamide (400 mg/kg body weight), and were killed in groups of four after 2 or 4 days. (A) RT-PCR analysis of...
In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 ...
In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 ...
Previously, we and others showed that signals relayed through the murine T cell Ag 4-1BB enhance primary T cell responses, and that blocking the interaction of 4-1BB with its ligand results in decreased responses to polyclonal activators and to alloantigens. Because 4-1BB expression is induce...