近日,美国加州理工学院化学与化学工程系的Huiqian Huang(第一作者)、Linda C. Hsieh-Wilson(通讯作者)等人在PNAS上发表了题为“Chondroitin 4-O-sulfation regulates hippocampal perineuronal nets and social memory”的研究论文,发现4-氧-硫酸软骨素调节海马CA2亚区神经元周围基质网络以及兴奋性/抑制性突触平衡。敲除...
近日,美国加州理工学院化学与化学工程系的Huiqian Huang(第一作者)、Linda C. Hsieh-Wilson(通讯作者)等人在PNAS上发表了题为“Chondroitin 4-O-sulfation regulates hippocampal perineuronal nets and social memory”的研究论文,发现4-...
In the present study we show that several different heteromeric enzyme complexes composed of different combinations of four chondroitin synthase family members synthesized more CS chains when a GalNAc-linkage pentasaccharide structure with a non-reducing terminal 4-O-sulfation was the CS acceptor. In ...
HE Bülow,O Hobert - 《Neuron》 被引量: 397发表: 2004年 Tinkering with heparan sulfate sulfation to steer development Heparan sulfate (HS) proteoglycans, at the cell surface and extracellular matrix, facilitate ligand鈥搑eceptor interactions crucial to many physiological p... B Gorsi,SE Stringer...
Transfer of C4ST-1 cDNA into sog9 cells (sog9-C4ST-1) restored 4-O-sulfation and amount of CS, verifying that sog9 cells had a specific defect in C4ST-1. Furthermore, the expression of C4ST-1 rendered sog9 cells significantly more susceptible to HSV-1 infection, suggesting that CS ...
取本品l . O g ,加高于8 0 °C的水2 0 m l溶解后,立即观察,溶液应澄清。 单宁酸 取本品l.O g ,加热水20ml溶解后,置冰箱(0〜5°C)中冷却至没食子酸结晶析出后,立即过滤,滤液加1%的明胶氯化钠溶液(临用新制。取明胶0.5g,氯化钠5g,溶于温度不超过60°C的水50ml中,即得)5〜6滴,溶液应澄清...
During discharge of PbO 2 formed in this manner a PbSO 4 of extremely fine grain and dense structure was found, which protects PbO 2 against further discharge and thus prevents an irreversible sulfation of the corrosion layer. 展开 关键词: Experimental/ electrochemical electrodes hydrogen compounds...
glycosylation, GPI anchor formation, hydroxylation, iodination, methylation, myristoylation, oxidation, pegylation, proteolytic processing, phosphorylation, prenylation, racemization, selenoylation, sulfation, transfer-RNA mediated addition of amino acids to proteins such as arginylation, and ubiquitination. (...
Due to immature CYP3A4 metabolism, neonates interestingly demonstrate greater sulfation and glucuronidation. Acetaminophen is available in various dosage forms including liquid suspension, chewable tablets, oral tablets, injection, and suppositories. The half-life of acetaminophen is ~2 to 3 h in ...
(PBS-BSA) for 30 min, incubated with 1 μg/ml BSA, or Slit3 w/o 20 μg/ml Robo4-Ig in PBS-BSA for 2 h. After that, the cells were washed with PBS-BSA 3 times, 5 min each, and incubated with 1:3000 diluted anti-His-HRP in PBS-BSA for 1. After washing with PBS-BSA ...