In formula I, R is 1-4C satd. straight-chain or branched-chain alkyl; R' is 1-6C satd. straight-chain or branched-chain alkyl which may be interrupted with O, 2-tetrahydrofurfuryl; R is 1-4C satd. straight-chain alkyl or phenyl, but a compd. with R being methyl, R' being ethyl...
Novel 1,4-dihydropyridine derivatives of the formula I! are provided: ##STR1## wherein R.sup.1 represents a C.sub.1-4 alkyl group or a C.sub.3- 6 alkoxyalkyl group, R.sup.2 represents hydrogen or halogen, R. sup.3 is either nitro when R.sup.2 is hydrogen, or halogen when ...
Novel alkoxyalkyldihydropyridine esters of the formula (I) <IMAGE> wherein the radicals R to R<4> have the meaning given in Claim 1, may be prepared by reacting an appropriate ss-ketocarboxylic acid ester with an appropriate enamine and an appropriate aldehyde, the corresponding acid addition ...
Antihypertensive effects of some new nitroxyalkyl 1,4-dihydropyridine derivatives in rat model of two-kidney, one-clip hypertension Iran. J. Pharm. Res., 8 (2009), pp. 193-199 Google Scholar OnoHandkinura, 1981 M. OnoHandkinura Effect of Ca+2 antagonist, vasodilators, diltizem, nifedipi...
To determine the optimal structural features required for MDR-reversal, Shekari et al., synthesized 18 asymmetrical 1,4-DHPs with 3-pyridyl methyl carboxylate at C3, nitrophenyl or heteroaromatic rings at C4, as well as alkyl carboxylate at the C5 position, and determined their efficacy to ...
1. Structural studies of 1-alkyl-4-azolylidene-1,4-dihydropyridines and azolium azolate inner salts Nakamichi, N.,Kawashita, Y.,Hayashi,M.Oxidative Aromatization of 1,3,5-Trisubstituted Pyrazolines and Hantzsch 1,4-Dihydropyridines by Pd/C in Agetic... Ermitas,Alcalde,Immaculada,... - 《...
NEW MATERIAL:A compound expressed by formula I [Ar is phenyl or formula II; one of X<1> and X<2> is methyl and the other is amino; R<1> is alkyl, cycloalkyl or cinnamyl, etc.; R<2> is formula III (Ar' is aryl or heteroaryl; m is 1-3) or formula IV (Y is aralkyl or...
amino; R<1> is alkyl, cycloalkyl or cinnamyl, etc.; R<2> is formula III (Ar' is aryl or heteroaryl; m is 1-3) or formula IV (Y is aralkyl or heteroaralkyl; n is 1-3)] or acid-added salt of said compound. EXAMPLE:2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-...
The compounds of the formula <IMAGE> wherein R is alkyl having 1 to 4 carbon atoms or nitratoalkyl having 2 or 3 carbon atoms, and R' is nitratoalkyl having 2 or 3 carbon atoms, are disclosed. These compounds are useful as therapeutic agents for cardiovascular disorders such as coronary...
The present invention relates to compounds of the formula wherein each A is independently halo; Y is -(CH2)m-, -C(O)- or -S(O)-; R1 and R2 are independently C1-4 alkyl; R3 is substituted azacycloalkyl etc.; R4 is phenyl substituted at the 2-position with a substituent selected ...