T1AM and TA1 effects are mediated by histamine release, a finding which allows to define the existence of a novel signal connecting the thyroid with histamine. Furthermore, the evaluation of TA1/T1AM level might indicate neurodegeneration, the extent of its severity, but also represent a ...
T1AM analogs have already been synthetized and their therapeutical potential is currently under investigation. 3-iodothyronamine (T1AM) is a biogenic amine whose structure is closely related to that of thyroid hormone (3,5,3'-triiodothyronine, or T3). The differences with T3 are the absence ...
中文名称:T1AM-D4 盐酸盐 中文同义词:T1AM-D4 盐酸盐;3-碘甲状腺素类似物(乙氨基-1,1,2,2-D4) 盐酸盐;4-[4-(2-氨乙基)-2-碘苯氧基]苯酚-D4 盐酸盐 英文名称:3-Iodothyronamine-(ethylamino-1,1,2,2-d4) hydrochloride 英文同义词:4-[4-(2-amino-1,1,2,2-tetradeuterioethyl)-2-iod...
3-Iodothyronamine (T1AM) is a metabolite of thyroid hormone. It is an agonist at trace amine-associated receptor 1 (TAAR1), a recently identified receptor involved in monoaminergic regulation and a potential novel therapeutic target. Here, T1AM was studied using rhesus monkey TAAR1 and/or ...
Miyakawa M, Scanlan TS (2006) Synthesis of [125I]-, [2H]-, and [3H]- labeled 3-iodothyronamine (T1AM). Synth Comm 36:891-902Miyakawa M and Scanlan TS (2006) Synthesis of [125I]-, [2H]-, and [3H]-labeled 3-iodothyronamine (T1AM). Synth Commun 36:891-902....
Most in vivo effects of 3-iodothyronamine (3-T1AM) have been thus far thought to be mediated by binding at the trace amine-associated receptor 1 (TAAR1). Inconsistently, the 3-T1AM-induced hypothermic effect still persists in Taar1 knockout mice, which s
PSA55.48000 LogP4.79260 3-Iodothyronamine-d4 hydrochlorideMSDS 1.1 产品标识符 : 3-碘甲状腺素类似物(乙氨基-1,1,2,2-d4) 盐酸盐 产品名称 1.2 鉴别的其他方法 3-Iodothyronamine-(ethylamino-1,1,2,2-d4)hydrochloride T1AM-d4hydrochloride ...
3-iodothyronamine (T1AM), a novel antagonist of muscarinic receptors. Eur J Pharmacol (2016) 793:35-42. doi:10.1016/j.ejphar.2016.10.027Laurino A, Matucci R, Vistoli G, Raimondi L. 3-Iodothyronamine (T1AM), a novel antagonist of muscarinic receptors. Eur J Pharmacol (2016) ...
The aim of this study was to analyze the metabolic response to T1AM in the Djungarian hamster Phodopus sungorus . We measured the influence of T1AM (50mg/kg) on metabolic rate ( V O 2 ), body temperature ( T b ) and respiratory quotient (RQ) in this species and in BL/6 mice. T1...
BACKGROUND AND PURPOSE Preclinical pharmacology of 3-iodothyronamine (T1AM), an endogenous derivative of thyroid hormones, indicates that it is a rapid modulator of rodent metabolism and behaviour. Since T1AM undergoes rapid enzymatic degradation, particularly by MAO, we hypothesized that the effects...