Thyroid hormone metabolism produces a series of primary amines, namely thyronamines, at different degrees of iodination, including 3-iodothyronamine (T1AM). From what is known, T1AM presents some, but not all, of the requisites to be defined as a trace amine. In fact, T1AM recognizes TA...
iodothyronamines, which are probably generated by the combined action ofdeiodinasesandaromatic amino acid decarboxylase, activate a biogenic amine-like G-protein-coupled receptor (GPCR): namely,trace aminereceptor 1 (TAR1). T1AM, which is present both in the blood and in peripheral tissues, ...
3-iodothyronamine (T1AM) is a biogenic amine whose structure is closely related to that of thyroid hormone (3,5,3'-triiodothyronine, or T3). The differences with T3 are the absence of the carboxylate group and the substitution of iodine with hydrogen in 5 and 3' positions (Figure 1). ...
中文名称: T1AM-D4 盐酸盐 中文同义词: T1AM-D4 盐酸盐;3-碘甲状腺素类似物(乙氨基-1,1,2,2-D4) 盐酸盐;4-[4-(2-氨乙基)-2-碘苯氧基]苯酚-D4 盐酸盐 英文名称: 3-Iodothyronamine-(ethylamino-1,1,2,2-d4) hydrochloride 英文同义词: 4-[4-(2-amino-1,1,2,2-tetradeuterioethyl...
3-Iodothyronamine (T_1AM) is a novel relative of thyroid hormone that plays a role in critical body regulatory processes such as glucose metabolism, thermal regulation, and heart beating. This paper was aimed at characterizing time dynamics of T_1AM and its catabolite 3-iodothyroacetic acid (...
3-Iodothyronamine (T1AM) is a metabolite of thyroid hormone. It is an agonist at trace amine-associated receptor 1 (TAAR1), a recently identified receptor involved in monoaminergic regulation and a potential novel therapeutic target. Here, T1AM was studied using rhesus monkey TAAR1 and/or ...
It was concluded that T1AM specifically modulated fatty acid uptake in different tissues and can potentially serve as a therapeutical anti dyslipidemia agent. Key words: 3-iodothyronamine, lipoprotein lipase, white adipose tissue, skeletal muscle, heart muscle. 展开 ...
3-iodothyronamine T1AM is a novel endogenous thyroid hormone derivative that activates the G protein-coupled receptor known as trace animeassociated receptor 1 (TAAR1). In the isolated working rat heart and in rat cardiomyocytes, T1AM pr... W Lei,TJ Maher,RJ Wurtman 被引量: 4发表: 2013年...
(3=,5=-T2), 3,3=,5-triiodothyronine (3,3=,5- T3), 3,3=,5=-triiodothyronine (3,3=,5=-T3), thyroxine (T4), 3,5-diiodothy- ronamine (3,5-diam), 3,3=,5-triiodothyronamine (3,3=,5-triam), and 3,3=,5,5=- tetraiodothyronamine (tetram) were purchased from Henning-...
FMOC-3-IODO-L-TYROSINE 芴甲氧羰基-3-碘代酪氨酸羟基 134486-00-3 3-IODO-L-TYROSINE METHYL ESTER HYDROCHLORIDE 3-碘-L-酪氨酸甲酯盐酸 79677-58-0 T3AM.HCl,3,3',5-TriiodothyronaMine hydrochloride 3,3ˊ,5ˊ-三碘甲状腺乙胺盐酸盐 788824-70-4 Tizanidine hydrochloride 盐酸替扎尼定 64461-82...