3-氧代酰基-[酰基载体蛋白]还原酶,英文名称为3-oxoacyl-[acyl carrier protein] reductase,简称为FabG,是一种参与细菌脂肪酸生物合成途径的酶之一。 该酶能够将3-氧代酰基-[酰基载体蛋白]还原为3-羟基酰基-[酰基载体蛋白],是脂肪酸合成途径中一个重要的还原酶。在细菌中,这个途径是合成膜磷脂和细胞壁等生命...
We also modelled a third 3-oxoacyl-ACP reductase, which we annotated as Ab SDR. Despite containing residues for catalysis and the ACP coordinating motif, biochemical analyses showed limited activity against an acetoacetyl-CoA substrate in vitro. Inhibitors designed to target FabG proteins and thus ...
The NADPH-linked 3-oxoacyl-(acyl-carrier protein) (ACP) reductase (EC 1.1.1.100), also known as 'beta-ketoacyl-ACP reductase', has been purified from the m... Administrator,WNC Br - 《Biochemical Journal》 被引量: 61发表: 1990年 Auxenochlorella protothecoides 3-oxoacyl-[acyl-carrierprot...
FABG POLYPEPTIDES ( 3-OXOACYL- [ ACYL-CARRIER PROTEIN ] REDUCTASE ) INVOLVED IN BACTERIAL FATTY ACID SYNTHESIS 来自 百度文库 喜欢 0 阅读量: 57 申请(专利)号: WO2006US45969 申请日期: 2006-12-01 公开/公告号: WO2007064865A3 公开/公告日期: 2008-01-10 ...
ketoacyl-thioesters are unstable, the reactions contained the purifiedE. colifatty-acid synthetic enzymes; 3-ketoacyl-ACP reductase (FabG), 3-hydroxyacyl ACP dehydratase (FabA), and enoyl-ACP reductase (FabI) and NADH to convert the condensation product to the stable fully saturated form. By ...
FABG POLYPEPTIDES ( 3-OXOACYL- [ ACYL-CARRIER PROTEIN ] REDUCTASE ) INVOLVED IN BACTERIAL FATTY ACID SYNTHESISThe present invention relates to polypeptide targets for pathogenic bacteria. The invention also provides biochemical and biophysical characteristics of those polypeptides.BERMAN JUDD M....
FABG POLYPEPTIDES ( 3-OXOACYL- [ ACYL-CARRIER PROTEIN ] REDUCTASE ) INVOLVED IN BACTERIAL FATTY ACID SYNTHESISThe present invention relates to polypeptide targets for pathogenic bacteria. The invention also provides biochemical and biophysical characteristics of those polypeptides.BERMAN, Judd, M....
3-oxoacyl-[acyl-carrier-protein] reductaseFabGstructure-based drug designfatty acid synthesisFASIIToxoplasma gondii is an opportunistic obligate parasite, ubiquitous around the globe with seropositivity rates that range from 10% to 90% and infection by the parasite of pregnant women causes pre-natal ...
FABG POLYPEPTIDES ( 3-OXOACYL- [ ACYL-CARRIER PROTEIN ] REDUCTASE ) INVOLVED IN BACTERIAL FATTY ACID SYNTHESISThe present invention relates to polypeptide targets for pathogenic bacteria. The invention also provides biochemical and biophysical characteristics of those polypeptides.BERMAN, JUDD, M....
Plasmid AZOBR_p1-borne fabG gene for putative 3-oxoacyl-[acyl-carrier ...Yulia A. Filip’echevaAndrei V. Shelud’koAlexei G. PrilipovGennady L. BuryginElizaveta M. TeleshevaStella S. YevstigneyevaMarina P. ChernyshovaLilia P. Petrova...