Functional expression of five Arabidopsis fatty acyl-CoA reductase genes in Escherichia coli. Very long chain primary alcohols are significant components in cuticle waxes of plants. Fatty acyl-CoA reductases (FARs) catalyze the formation of a fatty ... TTP Doan,AS Carlsson,M Hamberg,... - 《...
Fatty acyl alcohols are the key components for synthesis of wax. A fatty acyl-CoA reductase (FAR) is often essential in this biosynthetic pathway. The subcellular localization of FARs is crucial for understanding the process of synthesis and transport ...
EgWS utilized a broad range of fatty acyl-CoAs and fatty alcohols as substrates with the preference towards myristic acid and palmitoleyl alcohol. The wax biosynthetic pathway was reconstituted by co-expressi 展开 关键词: Euglena - Fatty acyl-CoA reductase - Fatty alcohol - Wax ester - Wax...
3-Ketosphinganine is rapidly converted tosphinganineby an NADPH-dependentreductase, thenceramidesyntase(s) acylate sphinganine todihydroceramidesusingfatty acyl-CoA'svarying in length from C16 to C30 (and usually saturated or mono-unsaturated) (Figure 2).Ceramidesynthase is actually a family ofenzymes...
LCFA-CoA esters promote their own oxidation by acting as allosteric inhibitors of acetyl-CoA carboxylase, which reduces the production of malonyl-CoA and relieves inhibition of carnitine palmitoyl-transferase 1, thereby promoting LCFA-CoA transport into the mitochondria for β-oxidation2,3,4,5,6....
With respect to genes in the PPAR signaling pathway, we found that lipoprotein lipase (lpl), long-chain fatty acid-CoA ligase 3 (ACSL3), acyl-CoA synthetase bubblegum family member 2 (ACSBG2), and long-chain fatty acid-CoA ligase 1 (ACSL1) were down-regulated in the FL group compared...
3. Low-polarity phases, such as polyneopenthylglycol succinate (NPGS), EGS with a phenyl-silicone (EGSP-Z™), Carbowax 20M™, and Silar 5CP™ EGSS-X™, EGSS-Y™, and newer phases of equivalent polarity are widely accepted as the most useful representatives of the first and sec...
Three enzymes are involved: 3-ketoacyl CoA reductase, 3-hydroxyacyl CoA dehydratase, and 2,3-trans-enoyl CoA reductase. In mammals, condensation reaction is catalyzed by enzymes of elongation, known as elongases of very-long-chain fatty acids (ELOVLs). There are seven ELOVLs including elon...
Alcohol-forming fatty acyl reductases (FARs) catalyze the reduction of thioesters to alcohols and are key enzymes for microbial production of fatty alcohols. Many metabolic engineering strategies utilize FARs to produce fatty alcohols from intracellular acyl-CoA and acyl-ACP pools; however, enzyme act...
We report on the functional characterization of fatty acyl-CoA reductases from birds. Based on the sequence similarity between FAR proteins, the respective cDNAs from chicken, barn owl and goose were cloned. Sequence similarities between the avian enzymes in conjunction with their expression pattern ...