摘要:消旋-3-正丁基苯酞 (dl-3-n-butylphthalide,NBP) 具有多种药理作用,具有多个药物靶点,近年丁苯酞适应证不断拓宽,本研究对NBP发挥神经保护作用的机制进行系统总结,包括保护血脑屏障、促进血管新生、抗血栓形成、改善能量代谢、抗氧化损伤、促进神经干细胞...
L-3-n-Butylphthalide (L-NBP)Alzheimer’s diseaseCognitionSynapseDendritic spineAlzheimer's disease (AD) is the most common cause of dementia among elderly people. Despite enormous efforts, the pathogenesis of AD still remains unclear and no drug has yet been proved to be disease-modifying. As ...
3- n -Butylphthalide (NBP) is a compound found in celery, and its potential therapeutic value in various disorders has been suggested. The benefits of NBP in dementia are among the most studied. Vascular dementia presents symptoms of cognitive impairment that are often originated from ...
DL-3-n-butylphthalide (NBP) is known to have neuroprotective effects via multiple mechanisms. This study aimed to investigate whether NBP can decrease neurological impairment after CA. We studied the protective role of NBP in the hippocampus of a rat model of cardiac arrest induced by asphyxia. ...
DL‐3‐n‐butylphthalide (NBP) is known to have neuroprotective effects via multiple mechanisms. This study aimed to investigate whether NBP can decrease neurological impairment after CA. We studied the protective role of NBP in the hippocampus of a rat model of cardiac arrest induced by asphyxia...
The present study intended to test the therapeutic potential ofdl-3-n-butylphthalide (NBP), a chemical compound extracted originally from the seeds of Chinese Celery, in the amelioration and prevention of Meth-induced neural injury. Experiments were carried out on SH-SY5Y cells. Neuronal injury ...
3-n-ButylphthalideNitricoxide-releasingderivativesAnti-plateletactivityMost ischemic stroke results from brain blood vessel blockage by platelet-mediated thrombus, and anti-platelet therapy has been demonstrated clinical benefits in the treatment of this disease. In the present work, novel nitric oxide (...