除外源性物质外,LCA及其氧化形式3-酮石胆酸(3-keto-LCA)对PXR有较强激活效应,而其余胆汁酸如CDCA、DCA、CA等则对PXR无激活作用[41]。与FXR相似,PXR作为核受体超家族成员,可通过与RXR形成异二聚体,结合靶基因调控区的同源DNA基序,进...
7β- A method for producing a hydroxylated system and a p-hydroxy derivative of lithocholic acid and 3-keto lithocholic acid from such systems is provided. Also, recombinant organisms useful for the production of plasmid encoding the enzyme system and such enzymes are also provided....
New Cobalt-Catalyzed Cycloisomerization Of ε-Acetylenic β-Keto Esters. Application To A Powerful Cyclization Reactions Cascade. J. Org. Chem. 61, 2699–2708, https://doi.org/10.1021/jo9600619 (1996). 21. Tolomelli, A. et al. Exploring The Reactivity Of Alkylidene Malonamides: Synthesis Of...
KETO-ENOL TAUTOMERISMPUSH-PULL SYSTEMA route for synthesizing C -nucleosides with 2,6-substituted pyridines as heterocyclic aglycones is described. Condensation of appropriately substituted lithiated pyridines with ribono-1,4-lactone derivatives yields hemiacetal 4a – g ( Table 1 ), which can be ...
Thus, ethyl 3-ketovalerate (4.3) g/1 (H 2 O) is converted in 40% yield to ( S )-3-hydroxyvalerate ( 6 ), with an enantiomeric excess of 93% (24 h at 72°).doi:10.1002/hlca.19850680420Dieter SeebachFabio GiovanniniBernd Lamatsch...
Catalytic hydrogenation of 19-hydroxy-A'-3-keto steroids affords predominantly A,B-cis dihydro derivatives. Unexpectedly, reduction in a lithium-ammonia system also gave substantial yields of the A,B-cis isomer. Hydrogenation of the es... LH Knox,EC Blossey,H Capio,... - 《Journal of Organ...
(3α,5β)-3-Hydroxy-7-oxocholan-24-oic acid; 7K-LCA; Hydroxycholanicacid; 5β-Cholanic acid, 3α-hydroxy-7-oxo-; 7-KETOLITHOCHOLIC ACID; 3α-Hydroxy-7-oxo-5β-cholanic acid; 3α-Hydroxy-7-oxo-5β-cholan-24-oic acid; Nutriacholic acid; 3α-Hydroxy-7-keto-5β-cholan-24-oic ...
3α-Hydroxy-7-keto-5β-cholan-24-oic acid; Nutriacholic acid; 3α-Hydroxy-7-oxo-5β-cholan-24-oic acid; 3α-Hydroxy-7-oxo-5β-cholanic acid; 7-KETOLITHOCHOLIC ACID; 5β-Cholanic acid, 3α-hydroxy-7-oxo-; Hydroxycholanicacid; 7K-LCA; (3α,5β)-3-Hydroxy-7-oxocholan-24-oic ...
具体来说,7-keto-LCA 通过抑制肠道 BA 受体、farnesoid X 受体 (FXR) 的信号传递来促进肠道上皮的修复。7-Keto-LCA 被证实是一种FXR抑制剂,可以促进 Wnt 信号传导,从而促进肠道干细胞的自我更新。这些结果显示了口服阿司匹林对肠道微生物群和肠道 BA 代谢的影响,而肠道 BA 代谢又会调节胃肠道的平衡状态[2]。
3α-Hydroxy-7-oxo-5β-cholanoic acid; 3α-Hydroxy-7-oxo-5β-cholic acid; 5β-Cholanic acid-3α-ol-7-one; 7-Ketochenodeoxycholic acid; 7- Ketolithocholic acid; 7-Oxo-3α-hydroxycholan-24-oic acid; 7-Oxolithocholic acid; 7-keto-Lithocholic acid; 7K-LCA; NSC 226118; Nutriacholic ...