Z. Jin, J.M. Berthiaume, Q. Li, F. Henry, Z. Huang, S. Sadhukhan, P. Gao, G.P. Tochtrop, M.A. Puchowicz, G.F. Zhang, Catabolism of (2E)-4-hydroxy-2-nonenal via omega- and omega-1-oxidation stimulated by ketogenic diet, J. Biol. Chem. 289 (2014) 32327-32338....
ALDH2 is a nuclear-encoded mitochondrial enzyme that is localized in the mitochondrial matrix, and mitochondria are the major source of ROS. Excessive ROS attacks polyunsaturated fatty acids leading to membrane lipid peroxidation, thereby generating reactive aldehydes, including 4-hydroxy-2-nonenal (4-...
While AA binds to proteins and DNA generating carcinogenic DNA adducts and inhibiting DNA repair and DNA methylation, ROS results in lipid peroxidation with the generation of lipid peroxidation products such as 4-hydoxynonenal which binds to DNA-forming highly carcinogenic exocyclic DNA adducts. ROS...
(3Z)-Nonenal(3Z)-Hexenal(2E)-4-Hydroxy-2-nonenal(2E)-4-Hydroxy-2-hexenal(2E)-4-Hydroperoxy-2-hexenalLipoxygenaseHydroperoxide PeroxygenaseHydroperoxide Lyase(2E)-4-Hydroperoxy-2-Nonenal3It is demonstrated that (3Z)-nonenal (NON) and (3Z)-hexenal (HEX) are oxidized in a cascade by lipoxygena...
- 2Method for producing 6-nonadienol andThe above (2e)6Z) - 2By the epoxidation reaction of 6-nonadienylThe following equation (8) (2e) - cis-67 - epoxy-2 - at least a step of obtaining a nonenal (2e) - cis-67 - provides an apparatus for producing epoxy 2 - nonenal.1 No sele...
Provided herein are convenient and efficient processes for preparing (2E,6Z)-2,6-nonadienal and (2E)-6,7-epoxy-2-nonenal with a reduced number of steps.Yuki MiyakeTakeshi KinshoTomohiro Watanabe
Also provided is a process for preparing (2E)-cis-6,7-epoxy-2-nonenal of the formula (8), comprising a step of subjecting (2E,6Z)-2,6-nonadienal thus obtained to epoxidation to form (2E)-cis-6,7-epoxy-2-nonenal.;\n\n\nYUKI MIYAKE...
PROBLEM TO BE SOLVED: To provide a simple and effective manufacturing method in a short process.;SOLUTION: There are provided a manufacturing method of (2E,6Z)-2,6-nonadienal including at least a process for obtaining a 1,1-dialkoxy-(6Z)-2,6-nonadiene compound represented by the following...
(2E)-4-Hydroperoxy-2-nonenalArnold Nola OnyangoNaomichi Baba
The object of the invention is to provide convenient and efficient processes for preparing (2E,6Z)-2,6-nonadienal and (2E)-6,7-epoxy-2-nonenal with a reduced number of steps.MIYAKE YukiKINSHO TakeshiWATANABE Tomohiro