Atherosclerosis is the most common cause of mortality in the Western world, contributing to about 50% of all deaths. Atherosclerosis is characterized by deposition of lipids onto the coronary or carotid arterial wall and formation of an atherosclerotic plaque. Atherosclerotic plaques are categorized ...
The cholesterol metabolite 27-Hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha. Cell Metab. 20, 172-182.Umetani, M., Ghosh, P., Ishikawa, T., Umetani, J., Ahmed, M., Mineo, C. and Shaul, P. W. (2014). The cholesterol metabolite...
单基因高密度脂蛋白代谢紊乱的人类和小鼠血浆中的 27-羟基胆固醇水平。| Karuna, R., et al. 2011. Atherosclerosis. 214: 448-55. PMID: 21130455 阿尔茨海默病中 27-羟基胆固醇对脑肾素血管紧张肽系统的上调作用。| Mateos, L., et al. 2011. J Alzheimers Dis. 24: 669-79. PMID: 21297254 ...
Jessup Oxysterols and atherosclerosis Atherosclerosis, 142 (1999), pp. 1-28 View PDFView articleView in ScopusGoogle Scholar Burkard et al., 2007 I. Burkard, A. von Eckardstein, G. Waeber, P. Vollenweider, K.M. Rentsch Lipoprotein distribution and biological variation of 24S- and 27-...
Macrophage death in advanced atherosclerosis promotes necrosis and plaque destabilization. A likely cause of macrophage death is accumulation of free chole... DeVries-Seimon,T. - 《Journal of Cell Biology》 被引量: 866发表: 2005年 TNF-alpha and IL-1beta selectively induce expression of 92-kDa ...
1Center for Research, Prevention and Treatment of Atherosclerosis, Hadassah University Hospital; 2Department of Pathology, Hadassah University Hospital; 3Department of Molecular Virology, Faculty of Medicine, Hebrew University, Jerusalem, Israel; 4Department of Medical Laboratory Sciences and Technology, ...
are very poor and lack specificity. The uptake of dietary cholesterol by Kupffer cells (KCs), the resident macrophages of the liver, was found to play an impor- tant role during NASH development [2]. Similar to previously reported observations during atherosclerosis [3,4], the Journal of ...
Atherosclerosis is currently understood to be mainly the consequence of a complicated inflammatory process at the different stages of plaque development. Among the several inflammatory molecules involved, up-regulation of the functional cyclooxygenase 2/membrane-bound prostaglandin E synthase 1 (COX-2/...
atherosclerosisMacrophages play a crucial role in atherosclerosis progression. Classically activated M1 macrophages have been found in rupture-prone atherosclerotic plaques whereas alternatively activated macrophages, M2, localize in stable plaque. Macrophage accumulation of cholesterol and of its oxidized ...
Phytosterol-enriched foods are increasingly marketed to lower cholesterol levels and atherosclerosis in the general population. Phytosterols reduce cholesterol absorption, but the molecular mechanism is controversial. We therefore investigated the phylosterol effects on cholesterol metabolism in human enterocyte,...