To gain further insights into the basis for antiviral activity, we evaluated time-dependent responses of the macrophage lipidome and transcriptome to 25OHC treatment. In addition to altering specific aspects of cholesterol and sphingolipid metabolism, we found that 25OHC activates integrated stress ...
Liu B, Xie C, Richardson JA, Turley SD, Dietschy JM (2007) Receptor-mediated and bulk-phase endocytosis cause macrophage and cholesterol accumulation in Niemann-Pick C disease. J Lipid Res 48:1710–1723. https://doi.org/10.1194/jlr.M700125-JLR200 Article CAS PubMed Google Scholar Liu Y...
25HC activates αvβ3 integrin in epithelial cell focal adhesions and macrophage podosomes. a Human lung epithelial cells (A549 cells) or differentiated THP-1 macrophages were subjected to various treatments and immunostained as indicated. In untreated (UT) A549 and THP-1 cells (first row), α...
ARTICLE Received 22 Dec 2015 | Accepted 6 Sep 2016 | Published 25 Oct 2016 DOI: 10.1038/ncomms13129 OPEN 25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome Jiho Jang1,*, Sangjun Park2,*, Hye Jin Hur1, Hyun-...
We further showed that production of 25-hydroxycholesterol (25-HC) promotes macrophage foam cell formation. Finally, deletion of ATF3 inApoe/mice led to in vivo increases in foam cell formation, aortic 25-HC levels, and disease progression. These results define a previously unknown role for ATF...
The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response Immunity., 38 (2013), pp. 106-118 View PDFView articleView in ScopusGoogle Scholar [14] A. Venkateswaran, J.J. Repa, J.M. Lobaccaro, A. Bronson, D.J. Mangelsdorf, ...
The receptor-mediated uptake of rat hypercholesterolemic very low density lipoproteins (beta VLDL) and rat chylomicron remnants was studied in monolayer cultures of the J774 and P388D1 macrophage cell lines and in primary cultures of mou... JL Ellsworth,FB Kraemer,AD Cooper - 《Journal of Biol...
Activation of LXR also substantially induced macrophage CH25H expression. In vivo, administration of GW3965 to mice increased CH25H expression in both liver and peritoneal macrophages. Taken together, our study demonstrates that 25-HC can activate CH25H expression in an LXR-dependent manner, which...
Here we report a cellular antiviral role for macrophage production of 25-hydroxycholesterol (cholest-5-en-3尾,25-diol, 25HC) as a component of the sterol metabolic network linked to the IFN response via Stat1. By utilizing quantitative metabolome profiling of all naturally occurring oxysterols ...
Activation of LXR also substantially induced macrophage CH25H expression. In vivo, administration of GW3965 to mice increased CH25H expression in both liver and peritoneal macrophages. Taken together, our study demonstrates that 25-HC can activate CH25H expression in an LXR-dependent manner, which...