作者团队首先放射合成了[131I]MIBG和[211At]MABG,并采用病毒转染建立NET表达神经母细胞瘤细胞系、通过腹部接种构建神经母细胞瘤动物模型,考察了[131I]MIBG和[211At]MABG的生物分布、毒性和疗效,并通过尾静脉注射接种的方式构建了转移性神经母细胞瘤动物模型,考察了[211At]MABG对转移微小疾病的疗效。研究结果表明[...
This tumor-reducing effect of 211At-MABG is similar to that of 131I-MIBG, which is one of the current treatment options (Zhao et al, SNMMI 2020, Pub #1316). The purpose of this study was to further evaluate the tumor growth suppression by repeated treatments with 211At-MABG in a ...
(s) 2022 Abstract In this manuscript, we present the guideline for use of meta-[211At] astatobenzylguanidine ([211At] MABG), a newly intro- duced alpha emitting radiopharmaceutical to the up-coming World's first clinical trial for targeted alpha therapy (TAT) at Fukushima Medical ...
Using a limiting dilution clonogenic assay, the cytotoxicity for SK-N-SH cells of [211At]MABG was compared with [211At]astatide and no-carrier-added [131I]MIBG. A D0 of 5.8 nCi/ml was calculated for [211At]MABG compared ... DK Strickland,G Vaidyanathan,MR Zalutsky - 《Cancer Resear...
When tumor volumes reached approximately 300 mm3, mice bearing PC-12 tumors received intravenously either 1.11 MBq of 211At-MABG (n=6), 31 MBq of 131I-MIBG (n=3) or vehicle solvent (n = 6). The tumor volume was measured 3 times per week for 2 weeks. The tumor volumes were ...
When tumor volumes reached approximately 300 mm3, mice bearing PC-12 tumors received intravenously either 1.11 MBq of 211At-MABG (n=6), 31 MBq of 131I-MIBG (n=3) or vehicle solvent (n = 6). The tumor volume was measured 3 times per week for 2 weeks. The tumor volume was compared...
5th, 2021. The study showed that patients receiving [211At] MABG do not need to be admitted to a radiotherapy room and that TAT using [211At] MABG is possible on an outpatient basis. The radiation exposure from the patient is within the safety standards of the ICRP and IAEA ...
Biodistribution and Dosimetry of Free 211At and Meta-[211At]astatobenzylguanidine (MABG) in Normal Micedoi:10.1016/j.jmir.2019.11.064Naoyuki UkonShongji ZhaoKohshin WashiyamaNoboru OriuchiHiroshi ItoJournal of Medical Imaging and Radiation Sciences...
Methods: Male normal mice (BALB/c, 9 weeks) received either 0.997 MBq of 123I-MIBG (equivalent to a human clinical imaging dose) or 0.483 MBq of 211At-MABG (a therapeutic dose in xenografted mouse model) intravenously. Mice were sacrificed by whole blood collection from the heart under ...