by reacting a fluoborate of formula: (II) with a phenethylamine of the formula H2NCH2CH(OR2)Ar (III) in a solvent (pref. a lower aliphatic alcohol, an ether, a halogenated lower alkane or an aromatic hydrocarbon), converting the resulting fluoborate of (I) into the free base, and ...
3. Probing the Binding Sites and Mechanisms of Action of Two Human Ether-a-go-go-Related Gene Channel Activators, 1 ,3-bis-(2-Hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-Dichloro-phenyl)-2,3-dihydro-1 H-isoindol-5-ylamino]-nicotinic acid (PD307243) [J] . Xu...
The filtrate was concentrated in vacuo and the residue was purified by silica gel column chromatography using ethyl acetate/petroleum ether (1/15, v/v) as eluent to obtain the product as a light yellow solid. Yield: 71%; Mp. 83-84 °C (HCl salt); 1H NMR (500 MHz, CDCl3)δ [ppm...
by reacting a fluoborate of formula: (II) with a phenethylamine of the formula H2NCH2CH(OR2)Ar (III) in a solvent (pref. a lower aliphatic alcohol, an ether, a halogenated lower alkane or an aromatic hydrocarbon), converting the resulting fluoborate of (I) into the free base, and ...
substd. phenyl) are prepd. by reacting (II) in an aromatic hydrocarbon and/or alkyl or aralkyl ether solvent at 25-80 degrees C with (III): R1-CHXCOOEt (III) (where X is halogen) in the presence of activated Zn metal (at least 1 mole to 1 mole of (II) and (III), treating ...
The salts were then recrystallized from ether. 2-(4-(ethylthio)-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethan-1-aminium chloride (25T2-NBOMe). Yield: 87%. 1H NMR (400 MHz, MeOD) δ: 7.46 (1H, ddd, J = 8.3, 7.4, 1.7 Hz, H4′), 7.37 (1H, dd, J = 7.5, 1.6 Hz, H6′)...