2-Oxoglutarate(2OG)-dependent dioxygenases(2-ODDs)are omnipresent iron-containing non-heme enzymes that catalyze various oxidation-reduction reactions in plant growth and development,nucleic acid modification and secondary metabolism.We systematically summarized recent research on the oxidative modifications ...
2-Oxoglutarate-dependent dioxygenases (2OGDDs) are a superfamily of enzymes that play diverse roles in many biological processes, including regulation of hypoxia-inducible factor-mediated adaptation to hypoxia, extracellular matrix formation, epigenetic regulation of gene transcription and the reprogramming ...
2-Oxoglutarate-dependent dioxygenases (2-ODDs) catalyze numerous steps in biosynthetic pathways of plants. Prohexadione-Ca is a known inhibitor of such rea... H Halbwirth,TC Fischer,K Schlangen,... - 《Plant Science》 被引量: 58发表: 2006年 2-Oxoglutarate-dependent dioxygenases in plants: ...
Chapter 1 Biochemical Diversity of 2-Oxoglutarate-Dependent Oxygenases 1 Robert P. Hausinger 1.1 Introduction 1 1.2 2OG-Dependent Dioxygenases that Act on Proteins 4 1.2.1 Protein Substrates with Structural Roles 4 1.2.2 Protein Substrates with Oxygen-Sensing Roles 4 1.2.3 Ribosomal Protein Hydrox...
Mechanisms of 2-oxoglutarate-dependent oxygenases: The hydroxylation paradigm and beyond In humans, Fe(ii)- and 2-oxoglutarate-dependent (Fe/2OG) oxygenases are generally of the dioxygenase subclass and mediate hydroxylation of unactivated aliphatic carbon centres. Plants and microbes also employ Fe/...
This review discusses recent advances in the biochemistry and molecular biology of dioxygenases occurring in different biological systems.关键词: 2-Oxoglutarate-dependent dioxygenase dioxygenase-related function mammalian microbial plant purification characterization kinetic parameters ...
The 2-oxoglutarate-dependent dioxygenase (2OGD) superfamily is the second largest enzyme family in the plant genome, and its members are involved in various oxygenation/hydroxylation reactions. Despite their biochemical significance in metabolism, a systematic analysis of plant 2OGDs remains to be acco...
Here, I surmise that the alpha-ketoglutarate dependent superfamily of non-haem iron (II) dioxygenases could influence cell physiology as a cohesive unit, and that the broad spectra of substrates transformed is an absolute necessity to this portrayal. This eclectic group comprises members from all ...
Here, by differential transcriptome mining, we identified six 2-oxoglutarate-dependent dioxygenase (2-ODD) genes whose expressions corresponded to tanshinone biosynthesis. We showed that Sm2-ODD14 acts as a dehydrogenase catalyzing the furan ring aromatization. In vitro Sm2-ODD14 converted ...
Can the stimulus-driven synergistic association of 2-oxoglutarate dependent dioxygenases be influenced by the kinetic parameters of binding and catalysis? In this manuscript, I posit that these indices are necessary and specific for a particular stimulus, and are key determinants of a dynamic clusterin...