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Mutations within the gene L2HGDH (Entrez Gene ID 79944) on chromosome 14q22 encoding L-2-hydroxyglutaric acid dehydrogenase have recently been shown to cause l-2-HGA in humans. Using a candidate gene approach in an outbred pet dog population segregating l-2-HGA, the causal molecular defect...
L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium) 是一种表观遗传修饰因子,是肾癌中的表观遗传修饰剂和推定的癌代谢物,可用于肾癌的相关研究。它抑制线粒体肌酸激酶活性,Km 和 Ki 分别为 2.52 mM 和11.13 mM。它可抑制组蛋白去甲基化酶,从而促进组蛋白甲基化。
Product Name 2-hydroxyglutaric acid Chemical Name 2-hydroxyglutaric acid CBNumber CB22681690 Molecular Formula C5H8O5 Formula Weight 148.11402 MOL File Mol fileMore Hazard and Precautionary Statements (GHS)2-hydroxyglutaric acid Preparation Products And Raw materials Raw materials Preparation Products...
L-2-Hydroxyglutaric acid disodium 是一种表观遗传修饰因子,可用于肾癌的相关研究,也可抑制线粒体肌酸激酶 (Mi-CK) 活性。 产品性质 英文别名(English Synonym) L-2-Hydroxyglutaric acid disodium 中文名称(Chinese Name) / 靶点(Target) Histone Demethylase;Mitochondrial Metabolism Others ...
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Urinary 2-hydroxyglutaric acid was 1418 mmol/mol creatinine (controls <25). Analysis of the L-2-hydroxyglutarate dehydrogenase gene revealed a homozygous mutation in exon 2 (A320G). At the age of 20 years, an osteoma of the right frontal bone was diagnosed. This finding reinforces the ...
Representative phosphoryl and thiophosphoryl derivatives of ( S )-glutamic or ( S )-2-hydroxyglutaric acid were synthesized and evaluated for their inhibitory potency against the glutamate carboxypeptidase, carboxypeptidase G (CPG). It was observed that the inhibition of CPG was highly sensitive to ...
Struys EA, Gibson KM, Jakobs C (2007) Novel insights into L-2-hydroxyglutaric aciduria: mass isotopomer studies reveal 2-oxoglutaric acid as the metabolic precursor of L-2-hydroxyglutaric acid. J Inherit Metab Dis 30(5):690–693. https://doi.org/10.1007/s10545-007-0697-5 Article CAS Pu...