The reaction of 2-OGM with LDH and the reaction of L-2-HG with GS generate L-2-hydroxyglutaramate (L-2-HGM). We also show that L-2-HGM is a substrate of human ω-amidase. The product (L-2-HG) can then be converted to 2-OG by L-2-HG dehydrogenase. Previous work showed ...