细胞摄入2DG后,经过细胞内生化酶的催化,通过检测产生的NADPH进行研究。 所有反应步骤都只需在同一个孔内添加预混试剂,即可实现自动化操作。 ●为减少葡萄糖代谢的影响,只需少量2DG加入活细胞中。通过细胞代谢将2DG转化转化为2DG6P。 ●2DG6P在被氧化的过程中会产生NADPH,通过检测NADPH的量来测定2DG6P的含量。
2-脱氧-D-葡萄糖(CAS号:154-17-6),简称2DG,是一种具有独特结构和广泛生物活性的化学物质。其分子式为C6H12O5,分子量为164.16,呈白色至近白色固体状态。近年来,2DG在科研领域的应用逐渐受到重视,尤其在药物研发、疾病诊断和治疗等方面展现出巨大的潜力。 二、产品特性 物理性质:2DG为白色至近白色固体,易溶于...
2DG regulates various cellular responses including proliferation, apoptosis and differentiation by regulation of glucose metabolism in cancer cells. However, the effects of 2DG in normal cells, including chondrocytes, are not clear yet. We examined the effects of 2DG on dedifferentiation with a focus...
运输条件:Evaluationsamplesolution:shipwithblueice Allotheravailablesize:shipwithRT,orblueiceuponrequest 生物活性 靶点:Others 信号通路:Hexokinase 产品描述: 2-Deoxy-D-glucose(2DG)(葡萄糖模拟物)是一个竞争性糖酵解的抑制剂[1-3]。细胞毒性试验中对KIT-阳性细胞株GIST882和GIST430的IC50值分别为0.5μM和...
2DG and glycolysis as therapeutic targets for status epilepticus Thomas P.Sutula,Nathan B.Fountain, inEpilepsy & Behavior, 2023 Abstract 2-deoxy-D-glucose(2DG) is a glucose analog differing from glucose only by removal of an oxygen atom at the 2 position, which prevents the isomerization of...
The intravenous injection of 2DG (250mgkg1) elicited an increase in tail skin temperature and decreases in body core temperature and the respiratory exchange ratio, though it did not induce any significant change in the metabolic rate. These results indicate that the hypothermic response was ...
[1]. 2-DG is readily transported into cells and is phosphorylated by hexokinase, but cannot be metabolized further and accumulates in the cell. This leads to ATP depletion and the induction of cell-death[2]. 2DG significantly suppresses proliferation, causes apoptosis and reduces migration of ...
D-2dGlc;nsc15193;deoxyglucose;2-deoxy-glucos;D-2-GLUCODESOSE;d-2-deoxyglucose;2-deoxy-d-glucos;2-Deoxy-D-mannose;D-Arabino-hexose, 2-deoxy-;arabino-Hexose, 2-deoxy-;D-Glucose, 2-deoxy-;9G2MP84A8W;(3R,4S,5R)-3,4,5,6-tetrahydroxyhexanal;2 Deoxyglucose;2 Deoxy D glucose;2 ...
2-Deoxy-D-glucose (2DG),是一种葡萄糖类似物,作为竞争性糖酵解抑制剂[1]。 2-脱氧-d-葡萄糖 (2DG) 已被证明是一种强大的药物,可阻断和探测癌细胞中增加的糖代谢[2]。由于其与葡萄糖的相似性,2-脱氧-D-葡萄糖抑制糖酵解,但在化学上它也是 2-脱氧甘露糖,它能够在 N-连接糖基化的初始步骤中与生...
D-2dGlc;nsc15193;deoxyglucose;2-deoxy-glucos;D-2-GLUCODESOSE;d-2-deoxyglucose;2-deoxy-d-glucos;2-Deoxy-D-mannose;D-Arabino-hexose, 2-deoxy-;arabino-Hexose, 2-deoxy-;D-Glucose, 2-deoxy-;9G2MP84A8W;(3R,4S,5R)-3,4,5,6-tetrahydroxyhexanal;2 Deoxyglucose;2 Deoxy D glucose;2 ...