PO1-15-02 Comprehensive characterization of genetic interactions in breast cancer reveals therapeutic vulnerabilities 乳腺癌基因相互作用的综合表征揭示了治疗的脆弱性 第一作者:Caijin Lin(复旦大学附属肿瘤医院) PO1-15-07 Subtyping-directed precision treatment...
Moderate Moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a sizeable possibility that it is substantially different (the intervention “probably results in” the effect). Low Confidence in the effect estimate is limite...
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simpler and cheaper to make than are antibodies or the other protein-based antivirals. Their well-known liability is generally low bioavailability due to degradation and metabolism when given systemically [113]. However, as a COVID-19 therapeutic,...
, Adolescent brain develop- ment: Vulnerabilities and opportunities (Vol. 1021, pp. 1–22). New York, NY: New York Academy of Sciences. Dahl, Ronald E., & Gunnar, Megan R. (2009). Heightened stress responsiveness and emotional reactivity during pubertal maturation: Implications for ...
However, the sensitivity and specificity of the RT-qPCR assay may be negatively affected by potential preanalytical and analytical vulnerabilities, including improper sample collection and processing as well as lack of harmonization of primers and probes with target genes [15,32,33]. Potential ...
Moderate Confidence: Judgments are based on information that is credibly sourced and plausible, but not of sufficient quantity or corroborated sufficiently to warrant a higher level of confidence. This level of confidence is used to express that judgments carry an increased probability of being incorrec...
Though variants of ACE2 have been engineered to increase their affinity to spike (and thus their neutralization potency) [49], optimized residues may introduce new vulnerabilities to escape. Alternatively, host-directed antibodies targeting ACE2 have circumvented this limitation and shown in vivo ...
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However, functional hippocampal deficits exist in both disorders,85,86 and increasing evidence suggests that schizophrenia and bipolar disorder share common genetic vulnerabilities.87 Our findings therefore provide further support for a reappraisal of these disorders as distinct diagnostic entities,32 although...