2-Deoxy-D-glucose (2-DG) 是葡萄糖的类似物,是一种糖酵解抑制剂。2-Deoxy-D-glucose 具有抗病毒活性,还具有抑制细胞增殖、诱导细胞凋亡的活性。 规格价格库存数量 100 mg¥ 153现货 500 mg¥ 326现货 1 g¥ 413现货 5 g¥ 987现货
D. Aging of membrane transport mechanisms in the central nervous system-high affinity glutamic acid transport in rat cortical synaptosomes. Exp. Gerontol. 15:265-284; 1980.Wheeler, D. D. 1981. Aging of membrane transport mechanisms in the central nervous system—2-deoxy- d -glucose transport ...
The glucose analogue 2-deoxy-d-glucose (2-DG) restrains growth of normal and malignant cells, prolongs the lifespan of C. elegans, and is widely used as a glycolytic inhibitor to study metabolic activity with regard to cancer, neurodegeneration, calorie restriction, and aging. Here, we report...
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Glucose uptake assay Mouse primary hepatocytes isolated from Tcf7l2f/f mice were infected with adenoviruses expressing gfp only and Cre and treated with 1 nmol/l insulin for 30 min. 2-Deoxyglucose (2-DG) levels in mouse primary hepatoc...
B Colony formation assay indicated that 2-deoxy-d-glucose (2-DG) or 3-bromopyruvate (3BrPA) inhibited Tiam1 overexpression-induced cell proliferation. C 3-[4,5-Dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) and D Matrigel tube formation assays. E Western blotting. F Transwell...
The glycolytic inhibitor 2-deoxyglucose activates multiple prosurvival pathways through IGF1R J. Biol., 284 (2009), pp. 23225-23233, 10.1074/jbc.M109.005280 Google Scholar [67] R. Gambino, J. Piscitelli, T.A. Ackattupathil, J.L. Theriault, R.D. Andrin, M.L. Sanfilippo, et al. Aci...
Cells were treated with injection compounds at the following concentrations for XF glycolysis stress test or XF Cell Mito test: 10 mM glucose (50-99-7, Sigma-Aldrich), 2 µM oligomycin (1404-19-9, Sigma-Aldrich), 50 mM 2-deoxy-D-glucose (2-DG) (154-17-6, Sigma-Aldrich), 1 ...
First, glucose analogues, such as 2-deoxy-d-glucose (2-DG), which can be metabolized by HK to 2-DG-6-phosphate, while it can no longer participate in downstream metabolism, which in turn affects the metabolism of the entire glycolytic pathway [5]. However, the high doses of 2-DG ...
Oxidative DNA damage in the brain has been implicated in neurodegeneration and cognitive decline. DNA glycosylases initiate base excision repair (BER), the main pathway for oxidative DNA base lesion repair. NEIL1 and NEIL3 DNA glycosylases affect cogniti