张进团队揭示细胞周期与胚胎干细胞2C状态进入与退出的关联 2012年Todd S. Macfarlan等科学家发现,在体外培养的小鼠ESCs具有异质性,有约1%的细胞在基因表达与染色质调控等方面与2-细胞期胚胎相似,这群细胞具有更高的发育潜能,它们既能分化成胚胎组织,又能够分化成胚外组织,因而被称作2-细胞样细胞(2-Cell Like Cell...
2012年 Todd S. Macfarlan 等科学家发现,在体外培养的小鼠胚胎干细胞(ESCs)具有异质性,有约1%的细胞在基因表达与染色质调控等方面与2-细胞期胚胎相似,这群细胞具有更高的发育潜能,它们既能分化成胚胎组织,又能够分化成胚外组织,因而被称作...
2022年6月2日,清华大学郗乔然和北京师范大学王占新共同通讯在Cell Stem Cell在线发表题为“A TRIM66/DAX1/Dux axis suppresses the totipotent 2-cell-like state in murine embryonic stem cells”的研究论文,该研究发现TRIM66 和 DAX1 一起作为 mESC 中 2C 样状态的负调节因子。 嵌合试验证实缺乏 TRIM66 或...
).值得注意的是,小鼠胚胎干细胞中含有少量的亚细胞群(小于1%),其基因表达模式类似2-细胞期胚胎,这一类细胞称为2-细胞期胚胎样细胞(2-cell embryo like cell, 2C-like cell).在适当的体外培养条件下,小鼠胚胎干细胞和诱导多能性干细胞(induced pluripotent stem cell, iPSC)中均会自发产生少量的2C-like细胞....
多种抑制rRNA生成的方法可以诱发核仁应激(nucleolar stress),导致核仁周边异染色质的变化从而解除对Dux等2C基因的抑制,最终促进ES细胞向2C-like细胞的命运转变。 2021年7月31日张进课题组在Protein & Cell杂志上发表的题为LIN28 Coordinately Promotes Nucleolar/Ribosomal Functions and Represses the 2C-like ...
综上所述,本研究首次发现了rRNA介导的核仁相分离和核仁周边异染色质的高级染色质结构能够调控ES细胞向2C-like细胞的命运转变;同时发现了rRNA生物发生是调控小鼠二细胞胚胎到四细胞胚胎转变的关键分子开关。本研究提供了一种将ES细胞重编程...
Zygotic genome activation (ZGA) marks the beginning of the embryonic program for a totipotent embryo, which gives rise to the inner cell mass (ICM) where pluripotent epiblast arises, and extraembryonic trophectoderm. However, how ZGA is connected to the
However, different inflammatory conditions can lead to various types of TH cell differentiation, resulting in the release of diverse cytokines22. TH2 cells predominantly secrete interleukin (IL)-4 and IL-13, potent pro-inflammatory cytokines that play critical roles in allergic diseases such as ...
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Like B cells, ___ must be activated to function in an immune response T cell receptors (TCRS) All T cells have surface receptors called T cells Unlike B cells, ___ do not recognize whole pathogen/protein MHC molecule for TCR recognition...