We present 3 patients as pitfalls of amyloid-beta (A[beta]) PET, who underwent 11C-PiB (A[beta]), 18F-MK-6240 (Alzheimer disease [AD]-tau), and 18F-THK5351 (astrogliosis) PET examinations. Despite negligible or tiny A[beta] pathology, patients 1 and 2 were diagnosed with AD as the...
Acta Neuropathologica Communications (2018) 6:53 https://doi.org/10.1186/s40478-018-0556-7 RESEARCH Open Access Neuroimaging-pathological correlations of [18F]THK5351 PET in progressive supranuclear palsy Aiko Ishiki1, Ryuichi Harada1,2,9* , Hideaki Kai3, Naomi Sato4, Tomoko Totsune5, Naoki...
基于18F-AV-1451PET/MR的阿尔茨海默病患者脑内tau蛋白沉积,脑萎缩与认知功能的关系研究 目的:采用一体化PET/MR同步采集MRI结构像及18F-AV-1451 PET图像,探讨AD及MCI患者脑内tau蛋白异常沉积和脑萎缩的改变模式及空间关系,以及tau蛋白沉积,脑萎缩与认知功能... 许欣茹 - 中国医科大学 被引量: 0发表: 2023...
我们评估了全脑[18F]THK5351 PET摄取作为tau/神经炎症的代用指标,并使用[18F]氟替他莫或[18F]氟betapir放射性示踪剂评估了全脑a β负荷。 结果 我们发现,较高的[18F]THK5351在脑干单胺能室摄取与皮质兴奋性增加相关(r = 0.29, P = 0.02)。相比之下,[18F]THK5351海马形成的PET信号虽然在全脑体素量化分析...
IDENTIFICATION OF HETEROGENEOUS GROUPS OF MILD COGNITIVE IMPAIRMENT BASED ON [18F]THK5351 RETENTION PATTERNSdoi:10.1016/j.jalz.2018.06.2278Young NohJoon-Kyung SeongDong Jin ShinKee Hyung ParkTatsuo IdoAlzheimer's and Dementia
The equation used to convert 18F-THK5351 to CL units was: CL = 100 (TauSUVR - 1.35)/0.324. The CL values for patients with NC and AD ranged from -144 to 104 (0.290 卤 54.9) and -111 to 234 (105 卤 90.9), respectively. Conclusions: Tau PET data with 18F-THK5351 can be ...
E-G 18F-THK5351 PET demonstrates abnormal accu- mulation in the frontal lobes with right-sided predominance, as well as the parietal lobes. 18F-THK5351 PET image was superimposed on brain computed tomography of the patient (F). Z score of 18F- THK5351 compared to 30 cognitively unimpaired ...
Harada R, Furumoto S, Tago T, Katsutoshi F, Ishiki A, Tomita N, Iwata R, Tashiro M, Arai H, Yanai K, et al. Characterization of the radiolabeled metabolite of tau PET tracer 18F-THK5351. Eur J Nucl Med Mol Imaging. 2016;43(12):2211-8. doi:10.1007/s00259-016-3453-y....
F]-THK5351 retention in the left inferior parietal and posterior temporal areas, while naming difficulty was correlated with retention in the left fusiform and temporal cortices. Conclusions The pattern of [18F]-THK5351 retention was well matched with clinical and radiological findings for each PPA...
18F-THK5351目的许多算法可抑制脑PET显像时的部分容积效应(PVE),而每种算法基于不同的假设和运算过程又有不同的特点.拟比较Tau蛋白和淀粉样蛋白PET显像时不同部分容积校正(PVC)方法的差异.方法研究了Tau蛋白和淀粉样蛋白PET显像时用到的最常用的2种PVC方法:穆勒-加特纳法(MG)和几何转换矩阵法(GTM)doi:10.3760/...