Meanwhile, 18F-P3BZA uptake in B16F10 tumors could be blocked by excess cold 19F-P3BZA (0.81 ± 0.02%IA/g, 88% inhibition, p < 0.05). PET/MRI 18F-P3BZA provided clear visualization of neuromelanin-rich SN at 30–60 min after injection in healthy macaques. The SN to cerebella ratios ...
Methods: Specific binding assay of 18F-P3BZA to NM was performed by testing the cell uptake of the probe in neuromelanotic PC12 cells, melanin-rich B16F10 cells, and amelanotic SKOV3 cells at 15, 30, 60, and 120 minutes post-incubation. Ex vivo biodistribution studies were also conducted...
The aim of the present study was to estimate the biodistribution and clinical radiation dosimetry of 18F-P3BZA in healthy volunteers and perform a preliminary clinical application for PET/CT imaging in melanoma patients. Methods: 18F-P3BZA was produced efficiently with a radiosynthesizer. Six ...
The tumor-to-liver ratio of [18F]DMPY2 was more than 4.5- and 7.6-fold higher than that of [18F]P3BZA and [18F]FBZA, respectively ([18F]DMPY2: 10.30 ± 2.22; [18F]P3BZA: 2.25 ± 0.36; [18F]FBZA: 1.35 ± 0.30; *P < 0.05; Fig. 1F).Conclusion: [18F]DMPY2 might have ...