使用18F-FBPA PET估算组织内硼绝对浓度的方法FBPAPET硼浓度目的建立一种估算组织内硼绝对浓度的实用方法,该方法通过4-二羟硼基-2-18F-氟-苯丙氨酸(18F-FBPA)PET显像的标准摄取值(SUV)计算硼浓度,并与静脉滴注4-二羟硼基-苯丙氨酸(BPA)后直接取各组织进行硼浓度测量的方法进行比较.方法研究对象为C6胶质瘤鼠...
18F-FBPA as a tumor-specific probe of L-type amino acid transporter 1 (LAT1): a comparison study with 18F- FDG and 11C-Methionine PET. Eur J Nucl Med Mol Imaging. 2017;44:321-31.Watabe T, Ikeda H, Nagamori S, Wiriyasermkul P, Tanaka Y, Naka S, et al. 18F-FBPA as a tumor-...
18F-FBPA as a tumor-specific probe of L-type amino acid transporter 1 (LAT1): a comparison study with 18F- FDG and 11C-Methionine PET. Eur J Nucl Med Mol Imaging. 2017;44:321-31.Watabe T, Ikeda H, Nagamori S, Wiriyasermkul P, Tanaka Y, Naka S, et al. 18F-FBPA as a tumor-...
18F-FBPABNCTBPAPharmacokineticsT/B ratioT/N ratioOBJECTIVE :The tumor-to-normal tissue (T/N) boron ratio is determined in a patient prior to boron neutron capture therapy (BNCT) using 4-borono-2- 18 F-fluoro-L-phenylalanine ( 18 F-FBPA) positron emission tomography (PET). The T/N ...
The SUVmax of 18F-FBPA was 3.92 卤 1.46 in grade 3, 3.21 卤 1.82 in grade 2, 2.33 卤 0.93 in grade 1, and 1.50 卤 0.39 in grade 0 of LAT1 expression. Although 18F-FBPA PET showed variable uptake in lung cancers and mediastinal tumors, benign lesions showed significantly lower SUV...
Electrophilic [18F]fluorinationWe modified a commercially available synthesis module for nucleophilic [18F]fluorinations (TRACERlabTM FXFDG, GE Healthcare) to enable the reliable synthesis of 2-[18F]fluoro-4-borono-l-phenylalanine ([18F]FBPA) via direct electrophilic substitution of 4-borono-l-...
The purpose of the current study was to evaluate the total distribution volume (Vt) of 18 F-FBPA in normal organs of healthy volunteers by kinetic analysis and to estimate boron concentration in normal organs for the therapeutic dose of 10 B-BPA using obtained Vt values.Six healthy volunteers...
The purpose of the current study was to evaluate the total distribution volume (Vt) of 18F-FBPA in normal organs of healthy volunteers by kinetic analysis and to estimate boron concentration in normal organs for the therapeutic dose of 10B-BPA using obtained Vt values. Six healthy volunteers ...
In contrast, relatively large overestimation was observed for the kidney (34.3 ± 29.3%), due to the influence of the high uptake in urine.The absolute boron concentrations in tissues/tumors can be estimated from the SUVs on 18F-FBPA PET using a practical formula. Caution must be ...
FBPATumor-to-normal ratio (T/N) measurement of18F-FBPA is crucial for patient eligibility to receive boron neutron capture therapy. This study aims to compare the difference in standard uptake value ratios on brain tumors and normal brains using PET/MR ZTE and atlas-based attenuation correction ...