BNCT尤其适用于胶质瘤、黑色素瘤等难治性肿瘤，并具有疗程短、生物效应高的优势。PET探针的关键作用：¹⁸F标记的4-硼基-2-氟苯丙氨酸（[18F]FBPA）作为BNCT的诊疗一体化探针，可通过PET成像非侵入性定量肿瘤内硼浓度，优化中子辐照时机和剂量，实现“治疗前预测-治疗中监控-治疗后评估”的全流程管理。二、[1...
18F-FBPA as a tumor-specific probe of L-type amino acid transporter 1 (LAT1): a comparison study with 18F- FDG and 11C-Methionine PET. Eur J Nucl Med Mol Imaging. 2017;44:321-31.Watabe T, Ikeda H, Nagamori S, Wiriyasermkul P, Tanaka Y, Naka S, et al. 18F-FBPA as a tumor-...
The SUVmax of 18F-FBPA was 3.92 卤 1.46 in grade 3, 3.21 卤 1.82 in grade 2, 2.33 卤 0.93 in grade 1, and 1.50 卤 0.39 in grade 0 of LAT1 expression. Although 18F-FBPA PET showed variable uptake in lung cancers and mediastinal tumors, benign lesions showed significantly lower SUV...
目的建立一种估算组织内硼绝对浓度的实用方法,该方法通过4-二羟硼基-2-18F-氟-苯丙氨酸(18F-FBPA)PET显像的标准摄取值(SUV)计算硼浓度,并与静脉滴注4-二羟硼基-苯丙氨酸(BPA)后直接取各组织进行硼浓度测量的方法进行比较.方法研究对象为C6胶质瘤鼠模型[n=7,体质量(241±28.0)g],静脉注射18F-FBPA(30.5±...
FBPATotal distribution volumeBoron neutron capture therapy (BNCT) is a noninvasive radiation therapy method for cancer treatment. In BNCT, 4-borono-2-[ 18 F]-fluoro-L-phenylalanine ( 18 F-FBPA) PET has been employed to estimate 10 B accumulation in target tumors and normal tissues if 10 B...
FBPABPABoron concentrationTotal distribution volumeBoron neutron capture therapy (BNCT) is a noninvasive radiation therapy method for cancer treatment. In BNCT, 4-borono-2-[18F]-fluoro-L-phenylalanine (18F-FBPA) PET has been employed to estimate 10B accumulation in target tumors and normal tissues...
18F]FBPAL-BPApreloadingIn recent years extra-corporal application of Boron Neutron Capture Therapy (BNCT) was evaluated for liver primary tumors or liver metastases. A prerequisite for such a high-risk procedure is proof of preferential delivery and high uptake of a10B-pharmaceutical in liver ...
•Uptake of [18F]FBPA was assessed in HuH-7, CaCo-2 and B16-F1 cells.•[18F]FBPA uptake is highly dependent on the incubation medium.•[18F]FBPA uptake was higher after preloading with L-BPA, L-DOPA and L-tyrosine.doi:10.1016/j.apradiso.2016.08.026Wingelhofer, Bettina...
Electrophilic [18F]fluorinationWe modified a commercially available synthesis module for nucleophilic [18F]fluorinations (TRACERlabTM FXFDG, GE Healthcare) to enable the reliable synthesis of 2-[18F]fluoro-4-borono-l-phenylalanine ([18F]FBPA) via direct electrophilic substitution of 4-borono-l-...
In contrast, relatively large overestimation was observed for the kidney (34.3 ± 29.3%), due to the influence of the high uptake in urine.The absolute boron concentrations in tissues/tumors can be estimated from the SUVs on 18F-FBPA PET using a practical formula. Caution must be ...