使用18F-FBPA PET估算组织内硼绝对浓度的方法FBPAPET硼浓度目的建立一种估算组织内硼绝对浓度的实用方法,该方法通过4-二羟硼基-2-18F-氟-苯丙氨酸(18F-FBPA)PET显像的标准摄取值(SUV)计算硼浓度,并与静脉滴注4-二羟硼基-苯丙氨酸(BPA)后直接取各组织进行硼浓度测量的方法进行比较.方法研究对象为C6胶质瘤鼠...
18F-FBPA as a tumor- specific probe of L-type amino acid transporter 1 (LAT1): a comparison study with 18F-FDG and 11C-methionine PET. Eur J Nucl Med Mol Imaging. 2017;44:321-31.Watabe T, Ikeda H, Nagamori S, Wiriyasermkul P, Tanaka Y, Naka S, et al. 18F-FBPA as a tumor-...
A reliable copper-mediated nucleophilic radiosynthesis of the PET imaging probe [18F]FBPA was developed using novel aryldiboron precursors. The carrier-free [18F]FBPA with radiochemical purity >99% was prepared routinely via the two-step synthesis with an automatic module and can be used for clin...
The purpose of the current study was to evaluate the total distribution volume (Vt) of 18 F-FBPA in normal organs of healthy volunteers by kinetic analysis and to estimate boron concentration in normal organs for the therapeutic dose of 10 B-BPA using obtained Vt values.Six healthy volunteers...
FBPABPABoron concentrationTotal distribution volumeBoron neutron capture therapy (BNCT) is a noninvasive radiation therapy method for cancer treatment. In BNCT, 4-borono-2-[18F]-fluoro-L-phenylalanine (18F-FBPA) PET has been employed to estimate 10B accumulation in target tumors and normal tissues...
The SUVmax of 18F-FBPA was 3.92 卤 1.46 in grade 3, 3.21 卤 1.82 in grade 2, 2.33 卤 0.93 in grade 1, and 1.50 卤 0.39 in grade 0 of LAT1 expression. Although 18F-FBPA PET showed variable uptake in lung cancers and mediastinal tumors, benign lesions showed significantly lower SUV...
We modified a commercially available synthesis module for nucleophilic [18F]fluorinations (TRACERlabTM FXFDG, GE Healthcare) to enable the reliable synthesis of 2-[18F]fluoro-4-borono-l-phenylalanine ([18F]FBPA) via direct electrophilic substitution of 4-borono-l-phenylalanine with [18F]F2 gas....
Electrophilic [18F]fluorinationWe modified a commercially available synthesis module for nucleophilic [18F]fluorinations (TRACERlabTM FXFDG, GE Healthcare) to enable the reliable synthesis of 2-[18F]fluoro-4-borono-l-phenylalanine ([18F]FBPA) via direct electrophilic substitution of 4-borono-l-...
18F-FBPABNCTBPAPharmacokineticsT/B ratioT/N ratioOBJECTIVE :The tumor-to-normal tissue (T/N) boron ratio is determined in a patient prior to boron neutron capture therapy (BNCT) using 4-borono-2- 18 F-fluoro-L-phenylalanine ( 18 F-FBPA) positron emission tomography (PET). The T/N ...
In contrast, relatively large overestimation was observed for the kidney (34.3 ± 29.3%), due to the influence of the high uptake in urine.The absolute boron concentrations in tissues/tumors can be estimated from the SUVs on 18F-FBPA PET using a practical formula. Caution must be ...