Purpose N-benzyl-N-methyl-2-[7, 8-dihydro-7-(2-[18F] fluoroethyl) -8-oxo-2-phenyl-9H-purin-9-yl] acetamide ([18F] FEDAC) is a novel positron emission tomography (PET) tracer that targets the translocator protein (TSPO; 18 kDa) in the mitochondrial...
粘聚力测试常用的试验方法包括垂直拉伸法和间接牵引法,用于测试沥青与岩石、水泥混凝土等材料之间的粘结力。 三、软度和粘聚力的关系 沥青的软度和粘聚力有着密切的关系,软度越大,沥青在高温下越容易流动,分子间的吸引力也会下降,从而导致粘聚力减小;反之,软度越小,沥青粘聚力越大,分子间的吸引力越...
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[18F]FEDAC was also applied in an MI rat model and in sham-operated controls. Mitochondrial changes were observed by immunohistochemical staining and electron microscopy.#Radioactivity levels (%ID/g) in the myocardium in normal mice, determined by [18F]FEDAC, were 8.32±0.80 at 5min and 2.40...
18FTSPOPETMitochondrial dysfunctionMyocardial injuryBackground This study aimed to evaluate the biodistribution and kinetics of [ 18 F]FEDAC targeting the translocator protein TSPO in the myocardium, and to explore its use for the identification of mitochondrial dysfunction. We also assessed the ...
This study aims to investigate the safety, biodistribution, and radiation exposure of [18F]FEDAC in healthy adult males.Kentaro TamuraRyuichi NishiiKotaro TaniEtsuko ImabayashiKana YamazakiTatsuya HigashiJournal of Nuclear Medicine
TSPO PET imaging using [18F]FEDAC probe reflects the activation state of UCP1 in BAT. These tools offer an opportunity to identify pharmacologic modulators of UCP1 expression and uncover regulatory pathways that impact BAT-mediated thermogenesis. ![Figure][1] [1]: pending:yesShuo Jiang...
Efficient radiosynthesis and non-clinical safety tests of the TSPO radioprobe [18F]FEDAC: Prerequisites for clinical application - ScienceDirectFEDACF-18TSPOPETExtended single-dose toxicity studyIntroduction: [F-18]FEDAC ([F-18]1) has potent binKazunori Kawamura a...
Bioorg Med Chem Lett 2009 19 , 1707-1710 [ 18 F]FEAC and [ 18 F]FEDAC: Two novel positron emission tomography ligands for peripheral-type benzodiazepine receptor in the brain .Yanamoto K, Kumata K, Yamasaki T, Odawara C, Kawamura K, Yui J, et al. [18F]FEAC and [18F]FEDAC: two...