戊戌数据合成工艺数据库提供CAS:的合成工艺信息查询,包括18F-FDDNP的基本信息,合成工艺流程图,合成工艺路线图以及原研企业Siemens Medical Solution;University Of California At Los Angeles的信息查询检索.
目的探讨标记物18F-FDDNP在脑断层扫描(PET)显像中诊断阿尔茨海默病(AD)的价值.方法分别对7例AD患者(AD组),6例血管性痴呆(VaD)患者(VaD组)及6例智能正常老年对照者(NC,NC组)进行18F-FDDNP脑PET显像,受试者分别在药物注射后5 min,25min和45min采集图像.结果AD患者3个时段放射性清除情况与其他2组图像有明显...
阿尔茨海默病的18F-FDDNP脑断层扫描显像 目的探讨标记物18F-FDDNP在脑断层扫描(PET)显像中诊断阿尔茨海默病(AD)的价值.方法分别对7例AD患者(AD组),6例血管性痴呆(VaD)患者(VaD组)及6例智能正常老年对照者(NC,... 贾建军,郭喆,汤洪川,... 被引量: 0发表: 2006年 自动化合成18F-FDDNP及其生物学分布 FDDNP...
6例VaD及6例智能正常老年对照者(NC)进行18F-FDDNP PET脑显像,受试者分别在药物注射后5、25、45 min采集图像.结果 AD患者大脑皮层及皮层下灰质核团3个时间段放射性清除情况与其他2组图像有明显的不同.药物注射5～45 min后脑内放射性
The purpose of the present study was to evaluate the performance of various parametric methods for quantification of [18F]FDDNP studies. All parametric methods tested were based on the use of a reference tissue and they were compared with the simplified reference tissue model (SRTM), as previously...
Detecting Alzheimer pathology in vivo: Comparing regional binding of [11C]PIB and [18F]FDDNPObjective: To evaluate associations of [(11)C]Pittsburgh compound B (PIB) and [(18)F]FDDNP with impairment in specific cognitive domains over the broader spectrum comprising cognitively normal elderly ...
mouse models (Tg2576 and dE9) expressing the AD pathology.We observed in in vitro, in vivo, and ex vivo studies that [18F]-FDDNP accumulated specifically in the Ab-overexpressing brain regions and that this accumulation wassignificantly reduced by co-incubation with non-radioactive FDDNP. In...
[18F]FDDNPamyloid plaquesAlzheimer's disease (AD)radiopharmaceuticalTRACERlab MXFDG[ 18 F]FDDNP has been recently described as a potent tracer to image amyloid plaques in vivo by positron emission tomography. Such a tool will be advisable to diagnose patient with mild cognitive impairment, to ...
Quantitative analysis of [18F]FDDNP PET using subcortical white matter as reference region. Eur J Nucl Med Mol Imaging 2010;37:575-88.Wong KP, Wardak M, Shao W, Dahlbom M, Kepe V, Liu J, et al. Quantitative analysis of [ 18 F]FDDNP PET using subcortical white matter as reference ...
Peripheral metabolism of [(18)F]FDDNP and cerebral uptake of its labelled metabolites. Nucl Med Biol. 2008; 35:869-874. [PubMed: 19026948]Peripheral metabolism of [18F]FDDNP and cerebral uptake of its labelled metabolites. Luurtsema, G,Schuit, R. C,Takkenkamp, K,Lubberink, M,Hendrikse,...