18F-FPCIT探针的核心是其标记的氟-18（18F）核素，这是一种短寿命的放射性同位素，具有适宜的半衰期和能量，使其成为理想的示踪剂。通过与特定的分子结构相结合，18F-FPCIT探针能够在生物体内实现精准的定位和示踪，为研究者提供关于生物过程、疾病发展和药物作用机制的宝贵信息。在疾病诊断方面，18F-FPCIT探针可用于...
OBJECTIVES To use [18F]9-fluoropropyl-(+)-dihydrotetrabenazine (18F-DTBZ; [18F]AV-133) positron emission tomography (PET) to explore the characteristics of vesicular monoamine transporter type 2 imaging in patients with Parkinson diseas...
This study examined the biodistribution and dosimetry of a novel deuterated VMAT2 radioligand, D6-[18F]FP-(+)-DTBZ, comparing it head-to-head with its non-deuterated counterpart, [18F]FP-(+)-DTBZ (AV-133). Methods: Six (6) healthy volunteers received intravenous injections of D6-[18F]...
AV-133Parkinson’s diseaseDosimetryIn the central nervous system, type 2 vesicular monoamine transporters (VMAT2) are responsible for the reuptake of monoamines from synaptic junction back to pre-synaptic terminal vesicles. These transporters are functionally crucial as they reflect the integrity of ...
The vesicular monoamine transporter type 2 (VMAT2) is co-expressed with insulin in β-cells and represents a promising target for BCM imaging.MethodsWe evaluated the VMAT2 radiotracer 18F-fluoropropyl-dihydrotetrabenazine ([18F]FP-(+)-DTBZ, also known as [18F]AV-133) for quantitati...
[ 18 F]AV-133), are useful for studying the changes in brain function related to monoamine transmission by in vivo imaging. Deuterated analogs have been reported targeting VMAT2 binding sites. METHODS: A novel deuterated [ 18 F]9-O-hexaduterofluoropropyl-(+)-dihydrotetrabenazine, [ 18 F]D...