黑龙江网讯（程亮 贾凡 记者 王忠岩）为满足临床医师及广大患者需求，哈医大肿瘤医院PET/CT-MRI中心在省内率先开展18F-AV133 PET/CT成像，对帕金森病（Parkinson’s disease，PD）进行精准诊断及评估，是我省首次应用18F标记囊泡单胺转运蛋白2（Vesicular monoamine transporter， VMAT2）进行显像。该分子成像特异度...
18F-FPCIT探针的核心是其标记的氟-18（18F）核素，这是一种短寿命的放射性同位素，具有适宜的半衰期和能量，使其成为理想的示踪剂。通过与特定的分子结构相结合，18F-FPCIT探针能够在生物体内实现精准的定位和示踪，为研究者提供关于生物过程、疾病发展和药物作用机制的宝贵信息。在疾病诊断方面，18F-FPCIT探针可用于...
Methods: The novel 18F-labeled tetrabenazine derivative, [18F ] AV-133, was used for the noninvasive assessment of the vesicular monoamine transporters type 2 (VMAT2) in 10 pdoi:10.1016/j.jalz.2010.08.006Svetlana Pejoska RNChristopher C. Rowe...
VMAT-II PET imaging with the tetrabenazine derivative, [18F]AV133, provides high quality images of striatal dopaminergic synaptic density with shorter uptake and imaging times than DAT SPECT. We therefore examined the management impact of [18F]AV-133 PET in CUPS.Methods 47 patients with CUPS ...
纹状体帕金森病放射性核素显像诊断帕金森病(Parkinson disease,PD)的方法较多,其中PET/CT功能显像方法在PD的早期诊断,鉴别诊断,病变严重程度分级及治疗效果的评价等方面都有重要价值[1].本研究对正常食蟹猴,单侧及双侧纹状体损毁的PD模型食蟹猴进行18F-AV-133PET/CT显像,研究大脑纹状体,额叶,颞叶,顶叶,枕叶,小脑,...
[18F]AV-133 合成的研究,取得较好的结果:当底物以-OTs 为离去基团,氟化反应在以K222/K2CO3 为催化剂、DMSO 为溶剂条件下进行时,120 oC 反应3 min 即可得到放化产率为80 ± 2%的产品.结论:本研究得到18F-烷基亲核取代反应的优化条件,并用于指导[18F]AV-133的合成,取得了较好的结果,有利于今后18F-放射性...
Background: Positron emission tomography (PET) provides a non-invasive means to evaluate the functional integrity of the presynaptic monoaminergic system in the living human brain. Methods: The novel 18F-labeled tetrabenazine derivative, [18F ] AV-133, was used for the noninvasive assessment of ...
Trial InformationBone & Cancer Foundation
[18F]AV-133Automatic synthesisPETIntroduction Recently, a PET tracer, 9-[18F]fluoropropyl-(+)-dihydrotetrabenazine ([18F]AV-133), targeting vesicular monoamine transporter 2 (VMAT2) in the central nervous system has been reported. It is currently under Phase II clinical trials to establish its...
doi:10.1016/j.jalz.2010.08.006Svetlana PejoskaChristopher C. RoweJohn DragoNobuyuki OkamuraRachel MulliganHank F. KungMichael PontecorvoColin L. MastersDaniel SkovronskyVictor L. VillemagneElsevier