2579 Introduction: C-X-C Chemokine Receptor 4 (CXCR4) is highly expressed in many malignancies and plays key roles in tumorigenicity and metastasis, correlating with prognostically poor outcomes. As such, targeted molecular imaging via positron emission tomography (PET) may enable the non-invasive ...
Aberg O, Pisaneschi F, Smith G, Nguyen QD, Stevens E, Aboagye E. 18F-Labelling of a Cyclic Pentapeptide Inhibitor of the Chemokine Re- ceptor CXCR4. J Fluorine Chem 2012; 135: 200-206.A˚ berg O, Pisaneschi F, Smith G, et al. 18F-labelling of a cyclic pentapeptide inhibitor of...
An in vitro study demonstrated high expression of chemokine receptor 4 (CXCR4) in APA, and an early clinical study confirmed the utility of 68Ga-labeled CXCR4 PET/CT imaging for detecting APA. This study evaluated the efficacy of 18F-ALF-NOTA-pentixather PET/CT for differentiating APA, IHA...
CXCR4PETAl18FAl18F-NOTA-SC[68Ga]PentixaFor detects C-X-C chemokine receptor type 4 (CXCR4) overexpression in various malignancies, such as multiple myeloma and non-Hodgkin lymphomas, as well as in endocrine and inflammatory disorders. This study aimed to develop an Al18F-labeled radiotracer ...
18FRadiosynthesisCXCR4DipyrimidineaminePyrimidine-pyridineamineIntroduction Chemokine receptor-4 (CXCR4, fusin, CD184) is expressed on several tissues involved in immune regulation and is upregulated in many diseases including malignant gliomas. A radiolabeled small molecule that readily crosses the blood...
Moreover, Al[18F]NOTA-T140 had high accumulation in CXCR4-positive metastatic tumors.#The simplicity of Al[18F]NOTA-T140 labeling along with its properties to specifically image CXCR4 expression by tumors warrant further clinical application for the diagnosis of CXCR4 clinically....
Herein, we introduce a novel and promising derivative, [18F]SFB-AMD3465, as a targeted PET tracer for CXCR4. The compound was synthesized by modifying the pyridine ring of AMD3465, which was subsequently labeled with 18F using [18F]SFB. The study provides comprehensive insights into the ...
Evaluation of [18F]FPy-T140 derivative PET imaging agents for CXCR4 in human cancer xenograft mouse modelsdoi:10.1016/S0969-8051(21)00298-5Tim PhelpsFalguni BasuliXiang ZhangColleen OlkowskiElaine JagodaNuclear Medicine and Biology
68Ga-Pentixafor PET/CT for imaging CXCR4/CXCL12 receptor-ligand axis in lung cancer- A head –to- head comparison with 18F-FDG PET/CT.2266 Introduction: Lung carcinomaremains the leading cancer killer worldwide despite ever evolving research and advances in diagnostic techniques & treatment ...
Role of [68Ga]-pentixafor-PET/CT as a novel imaging of cxcr4 expression in multiple myeloma; comparison to [18F]-FDG-PET/CTdoi:10.1016/S0145-2126(19)30253-XT. TiryakiS. KuyumcuD. Has-imekM. zbalakS. Kalayolu-BekLeukemia Research...