15-PGDH 基本信息 官方名 HPGD 官方全称 15-hydroxyprostaglandin dehydrogenase HGNC ID HGNC:5154 别称 15-hydroxyprostaglandin dehydrogenase (NAD(+)), SDR36C1, short chain dehydrogenase / reductase family 36C, member 1 位点类型 gene with protein product ...
一种独特的抑制剂 这项新的研究显示化合物SW033291通过抑制15-羟基前列腺素脱氢酶(15-hydroxyprostaglandin dehydrogenase, 15-PGDH)的作用减缓了心脏纤维化。15-PGDH能降解类花生酸(eicosanoids),而类花生酸是有助于防止纤维化的脂质信号分子。 图片来自Circulation Research, 2023, doi:10.1161/CIRCRESAHA.122.321475。
描述:Recombinant Human HPGD is produced by our Mammalian expression system and the target gene encoding Met1-Gln266 is expressed with a 6His tag at the C-terminus. Accession:P15428 中文别名:15-PGDH蛋白; HPGD蛋白 来源:Human Cells 纯度:Greater than 95% as determined by reducing SDS-PAGE. ...
The expression of 15-PGDH is ubiquitously down-regulated in various cancers. Whereas, overexpression of 15-PGDH in cancer cells causes apoptosis, cell cycle arrest, and inhibition of metastasis, and hence considered as a tumor suppressor. Hypermethylation of CpG islands in the gene promoter region ...
RayBio® Human 15-PGDH/HPGD ELISA Kit for Cell Culture Supernatants. CODE:ELH-15PGDH-1 Number of Plates: Antigen Information Accession Number: P15428 Gene ID: 3248 Gene Symbols: HPGD PGDH1 SDR36C1 Protein Name & Synonyms: 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH) (EC ...
2.1 COX-2、15-PGDH mRNA表达 COX-2 mRNA在正常结直肠黏膜、增生性息肉、腺瘤性息肉及结直肠腺癌中从低表达逐渐增加, 在腺癌组织中表达最高. 统计显示, 各组之间比较均有统计学意义(P<0.05, 表1). 而15-PGDH mRNA在正常结直肠黏膜、增生性息肉、腺瘤息肉及结直肠腺癌中从高表达逐渐降低, 在腺癌组织中呈低...
制;进一步以15.PGDH诱导药物对乳腺癌细胞进行干预,观察其是 否具有耐药逆转作用,以明确15.PGDH能否作为肿瘤耐药逆转的新 靶点。 方法:以人乳腺癌敏感细胞株MCF.7及阿霉素耐药细胞株 MCF一7/ADR为研究对象,加不同浓度ADM维持耐药,观察细胞形 态并用MTT法检测细胞耐药指数;应用RT.PCR、ELISA、Westem ...
The 15-PGDH gene was also transfected into the gastric cancer cell line SGC7901, which expresses endogenous 15-PGDH at a low level. When compared with the empty vector transfectant, MKN45 cells stably transfected with the 15-PGDH siRNA plasmid had a significantly increased proliferation rate. ...
英文别名 15 PGDH antibody | 15-hydroxyprostaglandin dehydrogenase [NAD+] antibody | 15-PGDH antibody | 15PGDH antibody | Hpgd antibody | Hydroxyprostaglandin dehydrogenase 15 (NAD) antibody | NAD+ dependent 15 hydroxyprostaglandin dehydrogenase antibody | OTTHUMP0 规格或纯度 重组, ExactAb™, 已...
Entrez Gene IDs 3248 (Human); 15446 (Mouse); 79242 (Rat) Alternate Names 15-hydroxyprostaglandin dehydrogenase [NAD+]; 15PGDH; 15-PGDH; EC 1.1.1; EC 1.1.1.141; HPGD; hydroxyprostaglandin dehydrogenase 15-(NAD); NAD+-dependent 15-hydroxyprostaglandin dehydrogenase; PGDH1; PGDH1PGDH; Prostagl...