10‐Formyltetrahydrofolate Synthetasedoi:10.1002/0471684228.egp04630This article has no abstract.American Cancer SocietyEncyclopedic Dictionary of Genetics, Genomics and Proteomics
Folatesactasdonorsofone-carbon(C1)unitsinallorganisms.TheseC1unitsexistatvariousoxidationstatesandareattachedtonitrogen5and/ortonitrogen10ofthepteridineringoffolates(CossinsandChen,1997).Inplants,tetrahydrofolate(THF)isactivatedwithformateinanATP-dependentmannerby10-formylTHFsynthetase(SYN;EC6.3.4.4)toyield...
The abbreviations used are: THF, tetrahydrofolate; FDH, 10-formyltetrahydrofolate dehydrogenase; MTHFD1, C1-tetrahydrofolate synthase; MTHFS, methenyltetrahydrofolate synthetase; SAM, S-adenosylmethionine; SAH, S-adenosylhomocysteine; pABG, para-aminobenzoylglutamate; FR, folate receptor; GAPDH, glycerald...
The 5,10-methenyltetrahydrofolate (5,10-CH=H4folate) synthetase catalyses the physiologically irreversible formation of 5,10-CH=H4folate from 5-formyltetrahydrofolate (5-HCO-H4folate) and ATP. It is not clear how (or if) 5-HCO-H4folate is formed in vivo. Using a spectrophotometric assay...
7. 18Oxygen incorporation into inorganic phosphate in the reaction catalyzed byN5,10-methenyltetrahydrofolate synthetase [O] . Kounga Kounga, Vander Velde David G., Himes Richard H. 1995 机译:N5,10-亚甲基四氢叶酸合成酶催化的反应中18O结合到无机磷酸盐中 8. Determination of Carbon-Center...
10-Formyltetrahydrofolate SynthetaseA key enzyme of folic acid metabolism. folic aciddoi:10.1007/978-1-4020-6754-9_6170Springer NetherlandsEncyclopedia of Genetics Genomics Proteomics & Informatics
Nour JM and Rabinowitz JC (1991) Isolation, characterization, and structural organization of 10-formyltetrahydrofolate synthetase from spinach leaves. J Biol Chem 266: 18363–18369Nour, J. M., and Rabinowitz, J. C. (1991). Isolation, characterization, and structural organization of 10-formyl...
The monofunctional enzyme 10-formyltetrahydrofolate synthetase (THFS), which is responsible for the recruitment of single carbon units from the formate pool into a variety of folate-dependent biosynthetic pathways, has been subcloned, purified, and crystallized. The crystals belong to space group...
The NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase : an optimized mitochondrial one-carbon folate pathwayChristensen, Karen E
5,10-Methenyltetrahydrofolate synthetase plays a significant role in folate metabolism by catalyzing the conversion of 5-formyltetrahydrofolate into 5,10-methenyltetrahydrofolate. The enzyme is important in some forms of chemotherapy, and it has been implicated in resistance to antifolate antibiotics....