尾-Arrestins can act as adapter molecules, coupling G-protein-coupled receptors to proteins involved in mitogenic as well as endocytic pathways. We have previously identified c-SRC as a molecule that is rapidly recruited to the 尾2-adrenergic receptor in a 尾-arrestin1-dependent manner. Recruitme...
β-arrestin1促进急性T淋巴细胞白血病Jurkat细胞衰老 目的:探讨β-arrestin1对急性T淋巴细胞白血病(T-ALL)细胞衰老的作用及其可能机制。方法:收集T-ALL患者骨髓样本和对照样本,应用RT-PCR和Western blot检测β-arrestin1... 郭维,刘姗,刘海燕,... - 《中国实验血液学杂志》 被引量: 0发表: 2019年 血浆t-PA与...
当它与不同的ω-3脂肪酸结合后,会分别激活不同的下游分子:Gq、Gs、Gi或β-arrestin 这些分子再分别通过钙离子、cAMP等第二信使来传递信号,最终发挥出不同的功能 一个关键问题便是,GPR120如何精准识别这些大同小异的脂肪酸分子而不混淆 这一问题的解决对相关药物研发至关重要 近期,浙江大学的研究团队在这一...
To investigate the signaling pathways involved in β-arrestin1-induced proliferation of K562 cells. METHODS We established stable cell lines K562-siβ1 and K562-β1 by lentivirus-mediated β-arrestin1 knock-down or overexpression in K562 cells, with cells ...