1 analogues in vitro,which lays a foundation for the screen-ing of GLP-1 analogues and small GLP-1 R agonists.%目的:以 GLP-1受体为靶点,建立 GLP-1类似物活性检测的细胞模型,为 GLP-1类似物以及 GLP-1受体激动剂的药物筛选提供一种简单可靠的评价方法.方法首先将人源 GLP-1受体基因插入 pEGFP-N3...
以GLP-1受体为靶点的药物筛选模型的建立及功能鉴定 黎思彤;郑雪萍;杨学敏;聂涛;陈健文;刘培庆;李民 【摘要】Aim To establish a cell model targeting on GLP-1 R,and evaluate its function by the cAMP assay,for screening the new class of GLP-1 analogues as anti-diabetic candidates. Methods An ...