Gamma-glutamylcysteine在谷胱甘肽合成过程中的作用不可忽视,它是通过谷氨酰半胱氨酸合成酶(Gamma-glutamylcysteine synthetase, GCS)催化谷氨酸和半胱氨酸反应生成的。这一步骤是GSH合成的限速步骤,意味着Gamma-glutamylcysteine的生成速率直接影响了GSH的最终产量。 进一步地,Gamma-glutamylcysteine作为谷胱甘肽过氧化物酶(Glutath...
GSH，也被称为谷胱甘肽或还原型谷胱甘肽，是一种广泛存在于动植物及微生物细胞中的三肽，具有极强的抗氧化性能，对于保护细胞免受氧化应激损伤至关重要。Gamma-glutamylcysteine在谷胱甘肽合成过程中的作用不可忽视，它是通过谷氨酰半胱氨酸合成酶（Gamma-glutamylcysteine synthetase, GCS）催化谷氨酸和半胱氨酸反应生成的...
GSH,也被称为谷胱甘肽或还原型谷胱甘肽,是一种广泛存在于动植物及微生物细胞中的三肽,具有极强的抗氧化性能,对于保护细胞免受氧化应激损伤至关重要。 Gamma-glutamylcysteine在谷胱甘肽合成过程中的作用不可忽视,它是通过谷氨酰半胱氨酸合成酶(Gamma-glutamylcysteine synthetase, GCS)催化谷氨酸和半胱氨酸反应生成的。这...
Sequential reactions of gamma-glutamylcysteine synthetase (gamma-GCS) and GSH synthetase; Extraction of cellular RNA and Northern blot; Effect of sublethal oxidative stress on gamma-GCS enzyme activity and on gamma-GCS-messenger RNA expression.Shi...
Wild AC, Mulcahy RT: Regulation of γ-glutamylcysteine synthetase subunit gene expression: insights into transcriptional control of antioxidant defenses. Free Radic Res 2000, 32 :281-301Wild A. C., Mulcahy R. T. 2000. Regulation of gamma-glutamylcysteine synthetase subunit gene expression: insights...
Glutathione is synthesized in two steps from amino acid precursors: the first step, where glutamic acid and cysteine are joined, is catalyzed by γ-glutamylcysteine synthetase (γ-GCS), while addition of glycine takes place at the second step by the catalysis of GS (Fig. 12.5). Sign in to...
gamma-Glutamylcysteine synthetase (gammaGCS) is a key regulatory enzyme in the synthesis of glutathione. It is a heterodimeric zinc metalloprotein that belongs to a unique class of proteins that gain activity due to formation of a reversible disulfide bond. The two subunits of gammaGCS exhibit ...
Article: Hydrogen peroxide increases the activity of gamma-glutamylcysteine synthetase in cultured Chinese hamster V79 cells
Overlapping antioxidant response element and PMA responseelement sequences mediate basal and beta-naphthoflavone-induced expression of the human gamma-glutamylcysteine synthetase catalytic subunit gene. 机译:重叠的抗氧化剂应答元件和PMA应答元件序列介导了基础和β-萘黄酮诱导的人γ-谷氨酰半胱氨酸合成酶催化...
We have cloned the human gamma-glutamylcysteine synthetase heavy subunit gene (GCSh) from a P1 library and isolated a 5.5kb fragment (P1-GCS5') from the 5'-end of the P1 clone. P1-GCS5' has been sequenced from -1460 to +547. Multiple transcription start sites were identified by primer...