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GSH,也被称为谷胱甘肽或还原型谷胱甘肽,是一种广泛存在于动植物及微生物细胞中的三肽,具有极强的抗氧化性能,对于保护细胞免受氧化应激损伤至关重要。Gamma-glutamylcysteine在谷胱甘肽合成过程中的作用不可忽视,它是通过谷氨酰半胱氨酸合成酶(Gamma-glutamylcysteine synthetase, GCS)催化谷氨酸和半胱氨酸反应生成的...
Gamma-glutamylcysteine在谷胱甘肽合成过程中的作用不可忽视,它是通过谷氨酰半胱氨酸合成酶(Gamma-glutamylcysteine synthetase, GCS)催化谷氨酸和半胱氨酸反应生成的。这一步骤是GSH合成的限速步骤,意味着Gamma-glutamylcysteine的生成速率直接影响了GSH的最终产量。 进一步地,Gamma-glutamylcysteine作为谷胱甘肽过氧化物酶(Glutath...
GSH,也被称为谷胱甘肽或还原型谷胱甘肽,是一种广泛存在于动植物及微生物细胞中的三肽,具有极强的抗氧化性能,对于保护细胞免受氧化应激损伤至关重要。 Gamma-glutamylcysteine在谷胱甘肽合成过程中的作用不可忽视,它是通过谷氨酰半胱氨酸合成酶(Gamma-glutamylcysteine synthetase, GCS)催化谷氨酸和半胱氨酸反应生成的。这...
It catalyses the ATP-dependent condensation between the gamma-carboxylate group of glutamate and the amino group of cysteine to form the...doi:10.1007/978-3-642-16483-5_2314Waseim BarriahVDM Verlag Dr. MüllerBiochemistrygamma-glutamylcysteine synthetase. Plant Physiol. 121:1169-1177....
Glutathione is synthesized in two steps from amino acid precursors: the first step, where glutamic acid and cysteine are joined, is catalyzed by γ-glutamylcysteine synthetase (γ-GCS), while addition of glycine takes place at the second step by the catalysis of GS (Fig. 12.5). Sign in to...
M. ( 1999 ) The induction of GSH synthesis by nanomolar concentrations of nitric oxide in epithelial cells: a role for γ-glutamylcysteine synthetase and γ-glutamyltranspeptidase . FEBS Lett. 448 , 292 – 296 .Moellering, (1999) FEBS Lett 448: pp. 292...
(1991) Molecular cloning of the gamma-glutamylcysteine synthetase gene of Saccharomyces cerevisiae. Yeast 7: 953-961.Ohtake Y, Yabuuchi S (1991) Molecular cloning of the gamma- glutamylcysteine synthetase gene of Saccharomyces cerevisiae. Yeast 7: 953±961...
A mutant of Escherichia coli, JTG10, deficient in gamma-glutamylcysteine synthetase (gamma-ECS; EC 6.3.2.2) is unable to synthesize glutathione (GSH) and i... M J,May,C J,... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 303发表: 1994...
Overlapping antioxidant response element and PMA responseelement sequences mediate basal and beta-naphthoflavone-induced expression of the human gamma-glutamylcysteine synthetase catalytic subunit gene. 机译:重叠的抗氧化剂应答元件和PMA应答元件序列介导了基础和β-萘黄酮诱导的人γ-谷氨酰半胱氨酸合成酶催化...