alpha#-mannosidosis in the human is an autosomal recessive lysosomal storage disease caused by a deficiency of lysosomal #alpha#-D-mannosidasea actvity. Lysosomal #alpha#-D-mannosidase is involved in the catabolism of N-linked glycoproteins through the sequential degradation of high-mannose, ...
During the course of a study of glycoprotein processing mannosidases in the rat epididymis, we have made an intriguing discovery regarding the presence of a novel alpha-D-mannosidase on the rat sperm plasma membranes. Unlike the sperm acrosomal "acid" mannosidase which has a pH optimum of 4.4,...
Human liver α d-mannosidase activity Three types of 伪-D-mannosidase activity have been found in normal human liver, acidic activity with a pH optimum of 4.25, neutral activity with a pH optimum of 6.5 and activity with an intermediate pH optimum of 5.5. The acidic activity... NC Phillips...
This chapter is focused on the N -glycan processing enzymes, ER α-mannosidase I (MAN1B1), and three Golgi α1,2-mannosidases (Golgi α-mannosidase IA (MAN1A1), Golgi α-mannosidase IB (MAN1A2), and Golgi α-mannosidase IC (MAN1C1)). Brief mention of the related EDEM proteins (...
Liberation of d-mannose from various glycoproteins by alpha-mannosidase isolated from Jack bean ... LI,Y.-T. - 《J. Biol. Chem》 被引量: 29发表: 1966年 Activity of exoglycosidases in ejaculated spermatozoa of boar and bull The activity of exoglycosidases in extracts from freshly ejaculated...
应用A fluorogenic enzyme substrate for α-D-mannosidase 储存温度-20°C储存 运输条件超低温冰袋运输 产品介绍 A fluorogenic enzyme substrate for α-D-mannosidase A fluorogenic enzyme substrate for α-D-mannosidase 关联靶点(人) 关联靶点(其它种属) ...
[2] K. Fujita, M. Kamiya, T. Yoshioka, A. Ogasawara, R. Hino, R. Kojima, H. Ueo, Y. Urano, Rapid and Accurate Visualization of Breast Tumors with a Fluorescent Probe Targeting α-Mannosidase 2C1, ACS Cent. Sci. 6(12) (2020) 2217-2227. ...
A Golgi preparation from Spodoptera frugiperda (IPLB-SF-21AE) cells was incubated in the presence of the mannosidase II inhibitor, swainsonine, with the oligosaccharide, M(alpha 1,3)[[M(alpha 1,3)[M(alpha 1,6)]M(alpha 1,6)]] M(beta 1,4)Gn(beta 1,4)Gn (M5Gn2), the preferred...
We have identified a mannosidase in rat liver that releases alpha 1---2, alpha 1---3 and alpha 1---6 linked manose residues from oligosaccharide substrates, MannGlcNAc where n = 4-9. The end product of the reaction is Man alpha 1---3[Man alpha 1---6]Man beta 1---4GlcNAc. Th...
We have investigated the vacuolar delivery of alpha-mannosidase, a marker enzyme of the vacuolar membrane in the yeast Saccharomyces cerevisiae, and found that the enzyme has several unique characteristics in its biosynthesis and vacuolar delivery. alpha-Mannosidase has no typical signal sequence (Yoshih...