alpha 6 beta 2 Nicotinic acetylcholine receptors (nAChRs) expressed by dopaminergic neurons in the CNS are potential therapeutic targets for the treatment of several neuropsychiatric diseases, including nicotine addiction and Parkinson disease. However, recent studies indicate that the alpha 6 subunit can...
Alpha. - conotoxin peptide txid, its pharmaceutical composition, and its use.The txid variant can specifically block the acetylcholine receptor (nach), especially the alpha 3. Beta. 4 or. Alpha. 6 /. Alpha. 3. Beta. 4 subtype, and medicines for regulating appetite for the treatment of ...
Critical residue identification of Alpha-conotoxin txid conferring potency for α3β4 nicotinic acetycholine receptor subtype through alanine scan mutagenesisdoi:10.1016/j.toxicon.2018.10.093Wu, YongZhu, XiaopengZhangsun, ManqiMcIntosh, J. Michael...
Characterization of a novel α-conotoxin TxID from Conus textile that potently blocks rat α3β4 nicotinic acetylcholine receptors. J. Med. Chem. 2013, 56, 9655–9663. [Google Scholar] [CrossRef] [PubMed] [Green Version] Franco, A.; Kompella, S.N.; Akondi, K.B.; Melaun, C.; ...
αO-conotoxin GeXIVA[1,2] was isolated in our laboratory from Conus generalis, a snail native to the South China Sea, and is a novel, nonaddictive, intramuscularly administered analgesic targeting the α9α10 nicotinic acetylcholine receptor (nAChR) with