α-突触核蛋白(α- SYN)和tau聚合成淀粉样纤维和形式intraneuronal丝状包裹体神经退行性疾病的特点。我们表明,α- SYN诱导纤维化tau蛋白和tau蛋白和α- Syn的协同促进的两个蛋白纤维化coincubation。在单一的转基因小鼠体内这些研究结果的相关性是在α- SYN和头丝状淀粉样蛋白在人类夹杂共生接地,A53T人类α- SYN表...
This has been confirmed using h-α-Syn containing the A53T mutation of familial forms of PD [20]. These mice did develop ubiquitin-positive inclusions in neurones suggesting Lewy body like α-Syn aggregates. Nevertheless, it should be noted that such cases model a small number of PD ...
While in the absence of DA, all alpha-syn PF exhibited identical stability, in its presence, the variant-composed PF acquired a greater stability (DAPFwt < DAPFA30P = DAPFA53T), implying that they would last longer, which could shed light onto why these mutations are so aggressive. When...
bvPLA2 treatment significantly ameliorated motor dysfunction in A53T Tg mice. In addition, bvPLA2 significantly reduced the expression of α-Syn, the activation and numbers of microglia, and the ratio of M1/M2 in A53T Tg mice. These results suggest that bvPLA2 could be a promising treatment...
bvPLA2 treatment significantly ameliorated motor dysfunction in A53T Tg mice. In addition, bvPLA2 significantly reduced the expression of α-Syn, the activation and numbers of microglia, and the ratio of M1/M2 in A53T Tg mice. These results suggest that bvPLA2 could be a promising treatment...