伪-Dicarbonyl compounds can be used to covalently modify and thereby inactivate prenylating enzymes such as protein farnesyltransferase and protein geranylgeranyltransferase. The compounds can be designed to enhance affinity and/or specificity for a particular protein substrate.Seth Rose...
alpha-Dicarbonyl compounds were trapped with o-phenylenediamine to give stable quinoxalines of d-arabino-hexos-2-ulose (glucosone), N(6)-(3,6-dideoxyhexos-2-ulos-6-yl)-l-lysine, 1-deoxy-d-erythro-2,3-hexodiulose (1-deoxyglucosone), 3-deoxy-d-erythro-hexos-2-ulose (3-deoxyglucos...
Also, increase in various alpha-dicarbonyl compounds, such as 3-DG, were observed in diabetic rate as compared with control rats. The reaction of alpha-dicarbonyl compounds with amino acids could lead to both ROS and AGE formation, which may contribute to the development and progression of ...
The preparation of a phosphorylated alpha-dicarbonyl compound designed to specifically react with arginine residues of enzymes accepting phosphorylated compounds as effectors is reported, and shown to inhibit rabbit muscle aldolase in a time-dependent and irreversible manner. This irreversible inhibition ...
α-Dicarbonyl compounds, particularly methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG), are highly reactive precursors for the formation of advanced glycation end products (AGEs). They are formed in vivo and during food processing. This study aimed to investigate the role of int...
Several dicarbonyl compounds, e.g. the α-keto aldehydes (I), the dialdehydes (III), and the diones (V), are treated with 2-propanol and catalytic amounts of zirconocene or hafnocene dihydride, performing a Meerwein-Ponndorf-Verley-type reduction to give selectively oxo alcohols such as ...
Meerwein-Ponndorf-Verley-type reduction of dicarbonyl compounds to hydroxy carbonyl compounds and .alpha.,.beta.-unsaturated carbonyl compounds to allylic ... Tatsuya Nakano ET AL: " Meerwein-Ponndorf-Verley-type reduction of dicarbonyl compounds to hydroxy carbonyl compounds and .alpha.,.beta.-...
ChemInform Abstract: EXCITED ELECTRONIC STATES OF THE ALPHA-DICARBONYLSstructure (organic substancesketones (benzene compoundsindan derivativesNois available for this article.doi:10.1002/chin.197438069ARNETT, J. F.NEWKOME, G.MATTICE, W. L.MCGLYNN, S. P....
The drawback here is the formation of alpha-dicarbonyl compounds, and they are associated with many metabolic disorders besides involving in the development of the desired flavor and browning. Cookies are one of the major sources of alpha-dicarbonyl compounds in diet. This study was performed to ...
alpha-Dicarbonyl compoundsMethylglyoxalGlyoxalBeveragesSoy milkMethylglyoxal (MGO) and glyoxal (GO), alpha-dicarbonyl compounds found in the Maillard reaction, progressively and irreversibly modify proteins. Beverages are an exogenous source of alpha-dicarbonyl compounds and may potentially increase MGO and ...