临床试验中,接受奥氮平治疗的患者出现有临床意义的QTc间期延长(基线QTcF500毫秒)并不常见(0.1%-1%),和安慰剂相比,没有统计学差异。但与其他抗精神病药一样,奥氮平与其他已知可以延长QTc间期的药物合用时要谨慎,尤其是在老年患者、先天性长QT综合征患者、充血性心脏衰竭患者、心肌肥厚、低钾血症或低镁血症的患者。 对奥氮
Alcohol— Ethanol (45 mg/70 kg single dose) did not have an effect on olanzapine pharmacokinetics. The co-administration of alcohol (i.e., ethanol) with olanzapine potentiated the orthostatic hypotension observed with olanzapine [see Drug Interactions (7.2)]. Inhibitors of CYP1A2 Fluvoxamine: ...
While there is no body of evidence to answer the question of how long a patient treated with ZYPREXA and fluoxetine in combination should remain on it, it is generally accepted that bipolar I disorder, including the depressive episodes associated with bipolar I disorder, is a chronic illness req...
Ethanol (45 mg/70 kg single dose) did not have an effect on olanzapine pharmacokinetics. The co- administration of alcohol (i.e., ethanol) with olanzapine potentiated the orthostatic hypotension observed with olanzapine [seeDRUG INTERACTIONS]. Inhibitors Of CYP1A2 Fluvoxamine, a CYP1A2 inhibitor,...