申请类型:NDA (新药申请) 申请人:WYETH PHARMS 申请人全名:WYETH PHARMACEUTICALS LLC 产品信息 产品号商品名活性成分剂型/给药途径规格/剂量参比药物(RLD)生物等效参考标准(RS)治疗等效代码该申请号批准日期该产品号批准日期市场状态 001ZOSYNPIPERACILLIN SODIUM; TAZOBACTAM SODIUMINJECTABLE;INJECTIONEQ 2GM BASE/VIAL...
How does piperacillin/tazobactam work (mechanism of action)? Piperacillin kills certain bacteria by preventing them from being able to create their cell wall. Some bacteria can produce substances that reduce the effects of piperacillin. Tazobactam destroys these substances, allowing piperacillin to keep ...
PIPERACILLIN; TAZOBACTAM (pi PER a sil in; ta zoe BAK tam) treats infections caused by bacteria. It belongs to a group of medications called penicillin antibiotics. It will not treat colds, the flu, or infections caused by viruses.
All but 1 lot demonstrated significantly decreased activity (-5 to -35%), necessitating further investigations regarding the chemical purity, potency, and therapeutic equivalence of these products worldwide. The average -16% activity across all generic lots was equivalent to underdosing piperacillin/...
The average −16% activity across all generic lots was equivalent to underdosing piperacillin/tazobactam by 2.6 g daily for serious clinical infections (4.5 g Q6 h).doi:10.1016/j.diagmicrobio.2007.12.010Ronald N. JonesThomas R. Fritsche...
JONES, R.N., FRITSCHE, T.R., MOET, G. J. In vitr o potency evaluations of var ious piper acillin/tazobactam gener ic pr oducts compar ed with the contempor ar y br anded (Zosyn(R), Wyeth) for mulation. Diagnostic Microbiology and Infectious Disease. 2008. 61: 76-79.JONES, R....