目的探讨肠激安方对腹泻型肠易激综合征(IBS-D)大鼠结肠黏膜超微结构及上皮细胞闭锁小带蛋白(ZO-1)和紧密连接蛋白(CLDN1)表达的影响.方法将40只SPF级新生SD大鼠随机分为正常组,模型组,匹维溴铵组(18 mg·kg^(-1))和肠激安方高(33.48 g·kg^(-1)),低(16.74 g·kg^(-1))剂量组,共5组,每组8只,...
本发明涉及人源化抗claudin1抗体及其用途.丙肝病毒感染是慢性肝病的主要原因,也是肝移植的主要指征.紧密连接蛋白claudin1(CLDN1)是HCV的必需入选因子,并且是治疗的有希望的靶标.对于临床开发,本发明人已经将通过遗传免疫产生的大鼠抗CLDN1抗体人源化,所述大鼠抗CLDN1抗体预防HCV感染并且还治愈慢性感染的人肝嵌合小鼠...
目的探讨肠激安方对腹泻型肠易激综合征(IBS-D)大鼠结肠黏膜超微结构及上皮细胞闭锁小带蛋白(ZO-1)和紧密连接蛋白(CLDN1)表达的影响.方法将40只SPF级新生SD大鼠随机分为正常组,模型组,匹维溴铵组(18 mg·kg^(-1))和肠激安方高(33.48 g·kg^(-1)),低(16.74 g·kg^(-1))剂量组,共5组,每组8只,采...
Our experiments have revealed endogenous tjp1 expression in protein and mRNA analyses of unfertilized Xenopus laevis oocytes expressing human claudin 1 (CLDN1) to claudin 5 (CLDN5). The amphibian cell model can therefore be used for the analysis of claudin interactions.Brunner, Nora...
Collective cell migration of epithelial tumor cells is one of the important factors for elucidating cancer metastasis and developing novel drugs for cancer treatment. Especially, new roles of E-cadherin in cancer migration and metastasis, beyond the epit