3c). Although the C-terminal C2H2 domain (aa 864–904) was dispensable for RQC of the reporter without compromising RNA cross-linking, the N-terminal RING domain (lacking in the 81–904 truncation) was required for RQC (Fig. 3d), albeit RNA cross-linking and thus translating ribosome ...
Tumor suppression by inducing NCOA4-mediated ferroptosis has been shown to be feasible in a variety of tumors, including gliomas. However, the regulatory mechanism of ferroptosis induced by NCOA4 in glioma has not been studied deeply. HECW1 and ZNF350 ar
DNA promoter methylation-dependent transcription of the double C2-like domain β (DOC2B) gene regulates tumor growth in human cervical cancer. J. Biol. Chem. 2014;289(15):10637–49. https://doi.org/10.1074/jbc.M113.491506. Article PubMed PubMed Central CAS Google Scholar Kaneda A, Waka...
C2C2,C2HC,C4C(HD),C3H,C3HC4,其中43%是C2H2型锌指蛋 白【4J。 C2H2型锌指蛋白家族很大,它包括700个以上的不同成员。C2H2 型锌指结构域是真核生物中最普遍的DNA结合序列,也是人类基因组 中编码得第二多的蛋白结构域。人类基因大概有30,000.40,000个,而其 ...
或C2HC。据估计有三分之一的锌指蛋白家族成员是KrUpple型 (即C2t_『2型)锌指蛋白,Krupple型锌指由25—30个氨基酸残基组 成,其中包含两个保守的Cys和HiS,其结构模式为c一2一C—X— H-3-H。而且KrUpple型锌指蛋白的一个典型特征是在前一个锌
ZCCHC10 suppresses lung cancer progression and cisplatin resistance by attenuating MDM2-mediated p53 ubiquitination and degradation ArticleOpen access28 May 2019 Main Lung cancer is one of the most lethal cancers throughout the world.1Approximately 85% of lung cancers are non-small cell lung cancer ...
ZNF131 protein has been placed in the superfamily of POK (BTB/POZ and krüppel) proteins, which contain a BTB/POZ domain in their N-terminal region as well as 5 typical C2H2 zinc fingers, and an additional C2HC zinc finger structure, in their C-terminus [28]. In POK proteins, including...
ZNF131 protein has been placed in the superfamily of POK (BTB/POZ and krüppel) proteins, which contain a BTB/POZ domain in their N-terminal region as well as 5 typical C2H2 zinc fingers, and an additional C2HC zinc finger structure, in their C-terminus [28]. In POK proteins, including...
In silico prediction revealed that the presence of the A allele creates a binding site for Myelin transcription factor 1-like, neuronal C2HC zinc-finger factor 1 (MYT1L, 2p25.3; matrix similarity ¼ 0.96), whereas the presence of the C allele creates a binding site for Homeobox and ...
C2HC C2H2 C2H2 UIM V5-6His : 1-228 (WT) V5-6His : 1-97 (N) C2H2 C2H2 UIM V5-6His : 98-228 (C) Input - + ++ WT WT N C 34 - 26 - Pull-down: Ni-NTA - + + + Flag-XAF1 WT WT N C ZNF313-V5-His Tubulin ZNF313 (V5) 17 - XAF1 RING C2HC C2H2 C2H2 UIM V5-...