用二甲苯基将尿喀啶与cyclen连接,合成了一种新的配体。并发现这种配体在水中能够与Zn2+快结合,生成的含锌配合物可以选择性地c进pUC 19质粒DNA的切割,而且这种配合物在c进 DNA切割过程中形成了一种稳定的大分子结构。 这种cyclen衍生物具有的多样性使它们在众多领域具有广的应用价值。例如,某些金属(如铜、锌等)...
A series of chiral peptides has been prepared, bearing a 1,4-dihydronicotine amide and a zinc cyclen moiety. The metal complex reversibly binds flavins in aqueous solution, while the dihydronicotine amide serves as a NADH model transferring a hydride to the flavin within the assembly. The ...
Zn2AzacrownA multi-nucleating azacrown conjugate (5a) consisting of two 3,5-bis(1,5,9-triazacyclododecan-3-yloxymethyl)benzyl groups attached to 1 and 7 sites of cyclen was prepared and tested as an artificial ribonuclease. The conjugate in the presence of five equivalents of zinc nitrate ...
以1,4,7,10-四氮杂环十二烷(Cyclen)为原料合成的一种新型双大环多胺配体及其双核Zn2+配合物,其结构用1HNMR,质谱和元素分析等测试技术进行了表征.以溴乙锭(EB)为探针,... 李硕,周成合,陈稼轩,向清祥 - 《应用化学》 被引量: 33发表: 2009年 新型席夫碱三核配合物的合成及其催化性能研究 以邻氨基苯甲...
As an important nucleobase in RNA, uracil was introduced into the side chain of cyclen (1,4,7,10-tetraazacyclododecane) by using phenylene dimethylene grou... CQ Xia,N Jiang,J Zhang,... - 《Bioorganic & Medicinal Chemistry》 被引量: 119发表: 2006年 Syntheses, Structures, and Properties ...
A pyrene-labeled Zn2+-cyclen complex for the staining of DNA in agarose gels is reported. The metal chelate coordinates reversibly to the DNA phosphate backbone, which induces the formation of pyrene excimers. The typical pyrene excimer emission is used for the detection of the DNA. Staining ...
We have previously shown that the nucleobase thymine binding to Zn2+ -cyclen (cyclen=1,4,7,10-tetraazacyclododecane) complex became stronger by appending acridine, naphthalene, or quinoline rings to the cyclen. Amongst these, the pendant bis((1-naphthyl)methyl) or bis((4-quinolyl)methyl) ...
The tris(ZnII−cyclen) complex is found to be a much better host toward phosphates than the parent ZnII−cyclen (ZnL1) (log Kaff = 3.3 for ZnL1−NPP2-) or a bis(ZnII−cyclen) linked with a m-xylene spacer (Zn2L2) (log Kaff = 4.0 for Zn2L2−NPP2-). 展开 ...
Kimura E,Ikeda T,Shionoya M,Shiro M.Molecular recognition of terephthalic acid by supramolecular self-assembly of an acridine-pendant cyclen-Zn(II) complex. Angew. Chem. In. Ed . 1995Kimura E,Ikeda T,Shionoya M,Shiro M.Molecular recognition of terephthalic acid by supramolecular self-assembly ...
双大环多胺,Zn(Ⅱ)配合物,合成,小牛胸腺DNA,荧光以1,4,7,10-四氮杂环十二烷(Cyclen)为原料合成的一种新型双大环多胺配体及其双核Zn2+配合物,其结构用1HNMR,质谱和元素分析等测试技术进行了表征.以溴乙锭(EB)为探针,用荧光光谱法研究了双环多胺配体及其Zn(Ⅱ)配合物与小牛胸腺DNA的作用,当cComplex6/cDNA...