The oral formulation of ziprasidone 20–60mg twice daily is well absorbed, with a maximum plasma drug concentration of 45–139 ng/mL. Systemic exposure was greater in the fed state than in the fasted state; thus oral ziprasidone should be taken with food. Ziprasidone is extensively metabolised...
Initially, 10–20 mg given as a single dose.Repeat doses of 10 mg every 2 hours or 20 mg every 4 hours, up to a maximum cumulative dosage of 40 mg daily.Oral therapy should replace IM therapy as soon as possible; safety and efficacy of administering ziprasidone IM injection for longer...
In healthy volunteers who received multiple doses of ziprasidone 20 to 60mg twice daily, the maximum plasma concentration (Cmax) of ziprasidone ranged from 44.6 to 139.4 μg/L, the area under the plasma concentration-time curve from 0 to 12 hours (AUC12h) ranged from 259.2 to 1027.9 μg ...
Adjustment of the dose can start at two days later, usually twice daily with the dose range being within 20~80mg and the maximum dose being 100mg. Patients of mild to moderate liver and kidney damage don’t need to adjust the dose. Ziprasidone is mainly metabolized in the liver with the...
Patients were randomly assigned to receive iloperidone (ILO) 8 mg [twice daily], ILO 12 mg [twice daily] (the maximum recommended therapeutic dose), ILO 24 mg [once daily], ziprasidone 80 mg [twice daily] (positive control) or quetiapine 375 mg [twice daily] (negative control) in the...
In animal studies, ziprasidone administration to pregnant rats and rabbits during organogenesis caused developmental toxicity at doses similar to recommended human doses, and was teratogenic in rabbits at 3 times the maximum recommended human dose (MRHD). Rats exposed to ziprasidone during gestation an...
(ziprasidone mesylate) is available as an injection forintramuscularuse. Geodon Capsules should be administered at an initial daily dose of 20 mg twice daily with food. For intramuscular dosing, the recommended dose of Geodon is 10 mg to 20 mg administered as required up to a maximum dose of...
In a randomised, open-label, crossover study, 14 healthy subjects were given a 40-mg dose of ziprasidone before and after taking 400 mg ketoconazole or a placebo daily for 6 days. It was found that the AUC and the maximum serum levels of the ziprasidone increased by 33% and 34% respect...
Acute treatment of agitation associated with schizophrenia (intramuscular administration): 10 mg-20 mg up to a maximum dose of 40 mg per day. Doses of 10 mg may be administered every 2 hours. Doses of 20 mg may be administered every 4 hours. (2.4) DOSAGE FORMS AND STRENGTHS • Caps...
a subject afflicted with an anxiety disorder who failed at least two courses of therapies with agents of different mechanisms of action (such as a course of Xanax at maximum tolerated doses for 4 weeks and a course of Effexor at 300 mg for 6-8 weeks, may be regarded as afflicted with ...