Zinc ionophores, molecules that carry zinc ions across the cell membrane, can decrease apoptosis in animals subjected to experimental heart attack, brain injury, neurodegeneration, and epilepsy. Here we show that zinc ionophores at low g/kg BW doses have neuroprotective effects in three different ...
1. A method of treating apoptosis comprising administering to a patient in need thereof a pharmaceutically effective amount of a zinc ionophore and a pharmaceutically acceptable carrier. 2. The method of claim 1, wherein the zinc ionophore is selected from the group consisting of zinc pyrithione...
P1.045 Zinc Ionophores Inhibit Herpes Simplex Virus Type 1 and 2 Replication Through Dysregulation of Ubiquitin-Proteasome PathwayBackground Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) are among the most prevalent human pathogens in both industrialised and developing regions. In the ...
Ca2+ ionophores are not suitable for inducing mPTP opening in murine isolated adult cardiac myocytes Opening of the mitochondrial permeability transition pore (mPTP) plays a major role in cell death during cardiac ischaemia-reperfusion. Adult isolated rode... Mathieu,Panel,Bijan,... - 《Scientific...
More recent studies using zinc ionophores have illustrated that zinc interferes with the autocatalytic processing of the viral protease 3CDpro into 3Cpro in the picornavirus coxsackievirus B3, thus inhibiting processing of the viral polyprotein (107). However, this was not the case for ...
To further explore the role of zinc in the modulation of NF-kappaB activation, we studied the effect of pyrithione, a zinc ionophore, on NF-kappaB activation in BCECs. Pyrithione inhibited NF-kappaB activity in a time- and dose-dependent manner. Ca-EDTA, but not Zn-EDTA, prevented ...
(HSV) virions, and the viral ubiquitin–proteasome pathway could be targeted with the zinc ionophore pyrithione to inhibit HSV-1 and HSV-2 infections [14,135,136,137]. Upon exposure to low endosomal pH, zinc binding with a specific histidine residue on the viral E1 protein can effectively ...
Because we found that chloroquine (CQ) causes arrested autophagy but clioquinol (ClioQ), a zinc ionophore, activates autophagic flux, in the present study, we examined whether ClioQ can overcome arrested autophagy induced by CQ or mutant presenilin-1 (mPS1). CQ induced vacuole formation and ...
The Potential Impact of Zinc Supplementation on COVID-19 Pathogenesis FOODS HIGH IN ZINC IONOPHORES (ACTIVATORS) During the current corona pandemic, new therapeutic options against this viral disease are urgently desired.Due to the rapid spread and immense number of affected individuals worldwide, cos...
This compound is a “zinc ionophore”—it opens a special “door” or “gate” in the cell membrane so that zinc can get into the cells. This may help boost your resistance to the SARS-CoV-2 virus at the cellular level, although that is still unproven. Dr. Zev Zelenko has what he ...