Engineered Zinc Finger Proteins for Targeted Genome Editing and Gene RegulationCarlos F. Barbas III
Zinc finger (ZnF) proteins are a massive, diverse family of proteins that serve a wide variety of biological functions.
Proteins containing the zinc finger domain(s) are named zinc finger proteins (ZFPs), one of the largest classes of transcription factors in eukaryotic genomes. A large number of ZFPs have been studied and many of them were found to be involved in regulating normal growth and development of ...
Researchers have engineered zinc finger proteins (ZFPs) to bind a diverse set of DNA sequences, and thereby target specific locations in the human genome, such as the promoters of therapeutically relevant genes. Exquisite specificity can be obtained with proteins that have six fingers. ZFP transcri...
The protein bears some similarity to zinc finger proteins, which are involved in DNA binding and protein-protein interactions. Alternative splicing results in two transcript variants encoding different proteins. Additional splice variants have been identified, but their biological validity has not been ...
摘要：The present dislosure relates to engineered zinc finger proteins that target genes in plants involved in fatty acid biosynthesis. Methods of using such zinc finger proteins in modulating gene expression, gene inactivation, and targeted gene modification are also provided.申请人：DOW AGROSCIENCES ...
Zinc Finger Protein 214 (ZNF214) (N-Term) 抗体说明 Antigen size: 606 AA 限制仅限研究用 贮存及处理 状态Lyophilized 溶解方式Add 100 µL of distilled water. 浓度1 mg/mL 缓冲液PBS buffer with 2 % sucrose 注意事项Avoid repeated freeze-thaw cycles. ...
The uteroglobin (UG) gene family encodes a fascinating group of secreted proteins that includes rat prostatic steroid-binding protein subunit C3, human Clara cell 10-kDa protein, human mammaglobin, and rabbit UG. In the rabbit, UG is a progesterone-dependent preimplantation uterine protein with pea...
genome-wide analysis of cchc-type zinc finger (zcchc) proteins in yeast, arabidopsis, and humans.[2020][cell mol life sci] 文档格式: .pdf 文档大小: 1.07M 文档页数: 24页 顶/踩数: 0/0 收藏人数: 0 评论次数: 0 文档热度: 文档分类: ...
"By inducing mutations in the CCR5 gene using zinc finger proteins, we've reduced the expression of CCR5 surface proteins on T cells, which is necessary for the AIDS virus to enter these immune system cells," explains first author Elena Perez, MD, PhD, Assistant Professor of Pediatrics at ...