Gli-similar protein 1 (GLIS1) (C2H2-type, transcription factor) is Krüppel-like zinc-finger protein involved in the pathogenesis of psoriasis. Indeed, GLIS1 is significantly overexpressed in psoriatic epidermis.135 GLIS1 mRNA is present only in the suprabasal layers of psoriatic skin, whereas no...
2.4. Additional Zinc Finger-Like Motifs A lot of poorly described protein structures are thought to be stabilized by the coordination of a zinc ion, existing as independent domains. They are grouped together on the basis that they do not form regular secondary structure elements upon the coordinat...
Using a DNA probe from the zinc finger region of EKLF, we cloned a cDNA encoding a member of this family from a human vascular endothelial cell cDNA library. Sequence analysis indicated that our clone, hEZF, is the human homologue of the recently reported mouse EZF and GKLF. hEZF is a ...
Here we describe Zim17, an essential protein with a zinc finger motif involved in protein import into mitochondria. Comparative genomics suggested a correction to the open reading frame of YNL310c, the gene encoding Zim17 in Saccharomyces cerevisiae. The revised open reading frame codes for a ...
The human ZNF521 was previously termed early hematopoietic zinc finger protein, and its expression in the hematopoietic system was restricted to a subpopulation of less differentiated CD34+ cells. ZNF521 is abundant in leukemia, medulloblastomas and other brain tumors. iRNA-mediated ZNF521 silencing ...
1. A fusion protein comprising: (a) a cleavage half domain; (b) a zinc finger protein comprising a non-canonical (non-C2H2) zinc finger, wherein the non-canonical zinc finger has a helical portion involved in DNA binding and wherein at least one zinc finger comprises the sequence Cys-(...
E. Structure of a histidine-X4-histidine zinc finger domain: insights into ADR1-UAS1 protein-DNA recognition. Biochemistry 33, 4460–4470 (1994). 42. Buetow, L. et al. Activation of a primed RING E3-E2-ubiquitin complex by non-covalent ubiquitin. Mol. Cell 58, 297–310 (2015). 43....
3. The zinc finger protein of claim 2, wherein the zinc finger protein binds to a SNP associated with a wild-type allele. 4. The zinc finger protein of claim 1, wherein the gene comprises one or more expanded trinucleotide repeats. 5. The zinc finger protein of claim 4, wherein the...
It is unlikely that the Leishmania protein contains a zinc finger. A Tb protein (Tb927.3.1610) has a CCCH motif in the middle of a kinase domain; the motif is absent from the other Tritryps despite of the high degree of conversion in this region (Figure 6B). Similarly, the previously...
zinc finger protein N A/C/G/T EP2C erythropoietin gene-binding protein 2C F1 F2, and F3, finger 1, finger 2, and finger 3 positions, respectively oligo oligonucleotide Transcriptional regulation is achieved mainly by transcription factors that bind to the cis-response elements in target gene ...