The invention provides zinc chelating agents and formulations thereof that deplete XIAP in cancer cells and sensitize the cells to apoptosis-inducing agents. The invention provides methods for sensitizing apoptosis-resistant cancer cells to apoptosis-inducing agents, as well as methods for treating a ...
These results confirmed the hypothesis that manipulations of intracellular pool of zinc by zinc-chelating agents may be a cause of both induction and prevention of apoptotic cell death in various pathological conditions. 展开 关键词: TPEN apoptosis hippocampus in vitro ...
The acidic environment of lysosomes would enhance ZnONPs dissolution and the sequential release of zinc ions.13 The high concentration of zinc ions directly induced cell death, which could be ameliorated by zinc-specific chelating agents such as DTPA or TPEN. Although TPEN was toxic at a ...
Diabetes mellitus is a group of metabolic disorders, the incidence of which varies widely throughout the world. The treatment of diabetes mellitus includes insulin, oral antidiabetic agents, and dietary regimens. Although the emphasis is on macronutrients intakes, there is strong evidence that there ...
Characterization of Major Zinc Containing Myonecrotic and Procoagulant Metalloprotease 'Malabarin' from Non Lethal Trimeresurus malabaricus Snake Venom with Thrombin Like Activity: Its Neutralization by Chelating Agents 来自 掌桥科研 喜欢 0 阅读量: 20 作者: CDR Gowda,HV Shivaprasad,RV Kumar,R Rajesh,...
Inhibition of the particle-associated RNA-dependent RNA polymerase activity of influenza viruses by chelating agents J Gen Virol, 23 (1) (1974), pp. 59-71 CrossrefView in ScopusGoogle Scholar 112 MJ Alter The epidemiology of acute and chronic hepatitis C Clin Liver Dis, 1 (3) (1997), pp...
Batch tests were used to illustrate the remobilization abilities of three chelating agents (ethylene-diaminetetraacetic acid, EDTA; diethylenetriamine pentaacetic acid, DTPA; ethylene glycol-bis (煤]-amino ethyl ether)-N-N鈥 -tetraacetic acid, EGTA) on zinc, as well as to realize the variation ...
Comparative study of different iron-chelating agents in cold-induced brain edema NA;Increasing numbers of reports demonstrate the importance of iron and oxygen free radicals in brain injury and brain edema. We investigated the protectiv... Y Ikeda,K Ikeda,DM Long - 《Neurosurgery》 被引量: 0发...
This enhancement of p21 levels corresponding to the apoptotic process was significantly blocked by the zinc ion chelating agents, EDTA, in a dose-dependent manner, demonstrating that cell growth arrest regulation was significantly dependent on cellular zinc ion levels. PIAS1/Smad2/4 complex and zinc...
Currently, four drugs are employed in patients with Wilson,s disease to eliminate copper, namely the copper chelating agent, penicillamine; trientine; tetrathiomolybdate, which forms a three-fold complex with copper and protein; and zinc.6 Treatment with zinc was introduced 1961 by Schouwink.94 ...